ESTRADIOL AND TESTOSTERONE LEVELS IN PATIENTS UNDERGOING PARTIAL-HEPATECTOMY - A POSSIBLE SIGNAL FOR HEPATIC REGENERATION
ESTRADIOL AND TESTOSTERONE LEVELS IN PATIENTS UNDERGOING PARTIAL-HEPATECTOMY - A POSSIBLE SIGNAL FOR HEPATIC REGENERATION
复制标题
DOI：
10.1007/bf01540264
复制
发表时间：
1989-06-01
影响因子：
3.1
通讯作者：
STARZL, TE
中科院分区：
文献类型：
--
作者：
FRANCAVILLA, A;GAVALER, JS;STARZL, TE
在5例接受40-60%肝部分切除术的成年男性患者中，测定了肝切除术前后血清性激素水平。每次手术前立即抽血，并在术后指定的时间点抽血。与手术前的激素水平相比，大肝切除术后，雌二醇水平在24和48小时升高，而睾酮水平下降，在96和144小时显著降低。这些数据表明，接受40-60%部分肝切除术的成年雄性小鼠的性激素水平变化与接受70%肝切除术的雄性大鼠相似。这些性激素水平的变化与动物肝脏性激素受体状态的改变有关，这被认为参与了再生反应的启动。这些研究表明，但没有证明，在人类中，就像在大鼠的情况下，性激素可能参与启动或至少部分调节发生在肝切除术后的再生反应。
In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testosterone levels decline, being significantly reduced at 96 and 144 hr. These data demonstrate that adult males who undergo a 40-60% partial hepatectomy experience alterations in their sex hormone levels similar to those observed in male rats following a 70% hepatectomy. These changes in sex hormone levels have been associated in animals with an alteration of the sex hormone receptor status of the liver that is thought to participate in the initiation of the regenerative response. These studies suggest, but do not prove, that in man, as in the case of the rat, sex hormones may participate in the initiation of or at least modulate in part the regenerative response that occurs following a major hepatic resection.