More favorable midlife cardiovascular risk factor levels in male twins and mortality after 25 years of follow-up is related to longevity of their parents.
More favorable midlife cardiovascular risk factor levels in male twins and mortality after 25 years of follow-up is related to longevity of their parents.
复制标题
男性双胞胎的中年心血管危险因素水平更高，25 年随访后的死亡率与其父母的寿命有关。
DOI：
10.1093/gerona/58.4.m367
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Williams,ChristopherJ
中科院分区：
文献类型：
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作者：
Reed,Terry;Carmelli,Dorit;Robinson,TiffanyS;Rinehart,ShannonA;Williams,ChristopherJ
背景：对人类寿命的遗传学研究使用了广泛的生存指标，最常见的是长寿，父母和后代之间存在适度的相关性。我们在国家心肺血液研究所的双胞胎研究中检验了男性双胞胎后代的遗传心血管疾病风险因素是否与其父母的寿命有关。方法：将前三次检查(受试者的平均年龄分别为48岁、58岁和63岁)测量的胆固醇水平、体重指数、血压和肺功能与双胞胎的父亲、母亲和父母的平均寿命(分为上五分之一和下五分之一)进行比较。结果：双胞胎，尤其是父亲较早去世的双胞胎，在中年有显著更高的总胆固醇(p<；.05)、总胆固醇与高密度脂蛋白的比率(p<；.01)和血压(p<；.01)。这种关系在随后的两次检查中有所下降，但父母寿命较长的双胞胎往往具有更好的风险因素特征。双胞胎死亡(平均年龄65岁)在有母亲(P<；.001)的家庭中明显更常见，父亲早逝的情况较少。载脂蛋白ϵ4等位基因在父母死亡年龄位于最低五分之一(p<；0.05)的家庭中更为常见。结论：收缩压、胆固醇水平和载脂蛋白Eϵ4等位基因的存在可能是文献中所报道的与长寿相关的家族性因素。
Background.Genetic studies of life span in humans have used broad survival measures, most commonly longevity, which is moderately correlated between parents and offspring. We examined whether genetic cardiovascular disease risk factors in male twin offspring are related to longevity of their parents in the National Heart, Lung, and Blood Institute twin study.Methods.Cholesterol levels, body mass index, blood pressures, and pulmonary function measured over the first three examinations (average subject age 48, 58, and 63 years, respectively) were compared with the twins' paternal, maternal, and parental mean longevity divided into upper versus lower quintiles. The presence of an apolipoprotein E ϵ4 allele typed from DNA collected at Exam 3 and mortality in the twin cohort through 1997 were also examined in relation to parental longevity quintiles.Results.Twins, particularly whose fathers died at younger ages, had significantly higher total cholesterol (p<.05), ratio of total cholesterol to high-density lipoprotein (p<.01), and blood pressures (p<.01) in middle age. This relationship decreased at the subsequent two examinations, but consistently, twins with longer-lived parents tended to have better risk factor profiles. A twin death (mean age 65) was significantly more common in families with mothers (p<.001) and, to a lesser extent, fathers who died early. An apolipoprotein ϵ4 allele was more common in families with parents' age at death in the lowest quintile (p<.05).Conclusions.Systolic blood pressures, cholesterol levels, and the presence of the apolipoprotein E ϵ4 allele likely contribute to the observed familial correlations in longevity that have been reported in the literature.