The determinants of bone mineral density in Chinese men - results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men
The determinants of bone mineral density in Chinese men - results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men
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DOI：
10.1007/s00198-005-2019-9
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发表时间：
2006-02-01
影响因子：
4
通讯作者：
Cauley, J
中科院分区：
文献类型：
--
作者：
Lau, EMC;Leung, PC;Cauley, J
Os先生(香港)是第一个研究亚洲男性骨质疏松症风险因素的研究。对2000名年龄在65-92岁的中国男性进行了标准化、结构化的访谈和双X射线密度测量(DEXA)。通过多元回归分析，发现以下因素与全髋部和脊柱的骨密度呈正相关：体重、握力和糖尿病病史。以下因素被发现与全髋部和脊柱的骨密度呈负相关：吸烟、胃或肠切除史、目前使用吸入性类固醇以及50年后骨折史。此外，慢性阻塞性肺疾病(COPD)病史与全髋部骨密度呈负相关，年龄、使用α-阻滞剂、噻嗪类利尿剂和硝酸酯类药物与脊柱骨密度较高有关。在多变量分析中，共解释了全髋关节和脊柱骨密度变异的21.8%和31.5%。
Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65-92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.