The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.
The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.
复制标题
视网膜上两极细胞中的转导级联：信号处理和疾病。
DOI：
10.1146/annurev-vision-102016-061338
复制
发表时间：
2017-09-15
影响因子：
6
通讯作者：
Sampath AP
中科院分区：
文献类型：
--
作者：
Martemyanov KA;Sampath AP
Our robust visual experience is based on the reliable transfer of information from our photoreceptor cells, the rods and cones, to higher brain centers. At the very first synapse of the visual system information is split into two separate pathways, ON and OFF, which encode increments and decrements in light intensity, respectively. The importance of this segregation is borne out in the fact that receptive fields in higher visual centers maintain a separation between ON and OFF regions. In the past decade the molecular mechanisms underlying the generation of ON signals have been identified, which is unique in its use of a G protein signaling cascade. In this review we consider advances in our understanding of G protein signaling in ON bipolar cell dendrites, and how insights about signaling have emerged from visual deficits, mostly night blindness. Studies of G protein signaling in ON-BCs reveal an intricate mechanism that permits the regulation of visual sensitivity over a wide dynamic range.
登录
查看更多内容
影响因子：
4.8
作者：
Connors, NC;Adams, ME;Kofuji, P
通讯作者：
Kofuji, P
影响因子：
5.3
作者：
Cao, Yan;Song, Hongman;Okawa, Haruhisa;Sampath, Alapakkam P.;Sokolov, Maxim;Martemyanov, Kirill A.
通讯作者：
Martemyanov, Kirill A.
DOI：
10.1523/jneurosci.1367-09.2009
发表时间：
2009-07-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cao Y;Masuho I;Okawa H;Xie K;Asami J;Kammermeier PJ;Maddox DM;Furukawa T;Inoue T;Sampath AP;Martemyanov KA
通讯作者：
Martemyanov KA
影响因子：
3.7
作者：
Brown, R. Lane;Xiong, Wei-Hong;Duvoisin, Robert M.
通讯作者：
Duvoisin, Robert M.
影响因子：
16.2
作者：
DeVries, Steven H.;Li, Wei;Saszik, Shannon
通讯作者：
Saszik, Shannon