Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia
Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia
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DOI：
10.1016/s0028-3932(03)00119-2
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Decety, J
中科院分区：
文献类型：
--
作者：
Brunet, E;Sarfati, Y;Decety, J
心理理论（ToM），将思想和感受归因于自己和他人的特定能力，通常在精神分裂症中受损。以往的研究表明，在有正式思维障碍的患者中，对他人的意图归因存在缺陷。在非语言任务中，这种功能需要对人物的视觉感知和对其意图的理解。这些过程被认为分别涉及上级颞沟和内侧前额叶皮层。精神分裂症患者与这些过程相关的激活功能模式是否异常？7例精神分裂症患者的药物进行了非言语归因的意图任务，以及两个匹配的物理逻辑任务，有和没有人的数字，而H2O15 PET扫描进行。这些患者的数据与8名语言智商和性别相匹配的健康对照者的数据进行了比较。实验设计允许分离的效果的感知的人的数字的归因的意图。在归因的意图，显着激活的右前额叶皮层中检测到的控制组。这些激活在精神分裂症组中没有发现。然而，在这两组中，人的形象的感知引起双侧激活的枕颞区和上级颞沟的后部。精神分裂症患者在进行非言语意图归因任务时，大脑活动异常。(C)2003爱思唯尔有限公司。保留所有权利。
Theory of mind (ToM), the specific ability to attribute thoughts and feelings to oneself and others is generally impaired in schizophrenia. Previous studies demonstrated a deficit of the attribution of intentions to others among patients having formal thought disorder. During nonverbal tasks, such a function requires both the visual perception of human figures and the understanding of their intentions. These processes are considered to involve the superior temporal sulcus and the medial prefrontal cortex, respectively. Are the functional patterns of activation associated with those processes abnormal in schizophrenia? Seven schizophrenic patients on medication performed a nonverbal attribution of intentions task as well as two matched physical logic tasks, with and without human figures, while H2O15 PET-scanning was performed. Data from the patients were compared to those of eight healthy controls matched for verbal IQ and sex. The experimental design allowed dissociating the effect of the perception of human figures from that of the attribution of intentions. During attribution of intentions, significant activations in the right prefrontal cortex were detected in the control subjects. Those activations were not found in the schizophrenic group. However, in both groups, the perception of human figure elicited bilateral activation of the occipitotemporal regions and of the posterior part of the superior temporal sulcus. Schizophrenic patients performing a nonverbal attribution of intentions task have an abnormal cerebral activity. (C) 2003 Elsevier Ltd. All rights reserved.