Electrocardiograms of menopausal women with coronary heart disease or at increased risk for its occurrence.
Electrocardiograms of menopausal women with coronary heart disease or at increased risk for its occurrence.
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患有冠心病或发生冠心病风险增加的更年期妇女的心电图。
DOI：
10.1016/j.amjcard.2010.07.032
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Barrett-Connor,Elizabeth
中科院分区：
文献类型：
--
作者：
Wenger,NanetteK;Mischke,JenniferM;Schroeder,Rolf;Schroeder,Klaus;Collins,Peter;Grady,Deborah;Kornitzer,Marcel;Mosca,Lori;Barrett-Connor,Elizabeth
绝经期合并冠心病（CHD）的妇女的心电图（ECG）特征尚不清楚。雷洛昔芬用于心脏（RUTH）试验的10101名参与者的数据被用来将基线心电图异常与临床特征联系起来。在单变量分析中，基线特征与ECG结果有统计学显著相关（p≤0.05），用于进行多变量模型选择。在59%的正常心电图中，50%来自冠心病女性，69%来自冠心病风险增加的女性。在患有冠心病的女性中，59%报告既往有心肌梗死（MI）；43%的人心电图正常，49%的人有明确的心电图q波心肌梗死。高危组的女性以前没有报告过心肌梗死，但11%的人有明确的心电图q波心肌梗死。在报告高血压的女性中，35%的人有左心室肥厚的心电图证据，但58%的人没有心电图异常。在高危组和记录在案的冠心病组中，明显有更多的糖尿病女性心电图异常（两组的p <0.01）。随着年龄的增加（55 ~ 64岁，65 ~ 74岁和≥75岁，p <0.01），所有队列的心电图异常百分比均有所增加。心绞痛和冠状动脉搭桥手术，但没有经皮冠状动脉介入治疗，预测心电图异常。总之，RUTH参与者中高危组和记录在案的冠心病组中，正常心电图的比例很高，心肌梗死史和心电记录之间存在很大差异，在所有3个队列中，年龄的增长是与心电图异常相关的主要因素。
Little is known about electrocardiographic (ECG) characteristics of menopausal women with or at increased risk of coronary heart disease (CHD). Data from 10,101 participants in the Raloxifene Use for The Heart (RUTH) trial were used to correlate baseline ECG abnormalities with clinical characteristics. Baseline characteristics that were statistically significantly associated (p ≤0.05) with ECG findings in univariate analyses were used to derive multivariate model selection. Of 59% normal electrocardiograms, 50% were from women with CHD and 69% from women at increased risk of CHD. In the women with CHD, 59% reported a previous myocardial infarction (MI); 43% had a normal electrocardiogram, and 49% had a definite ECG Q-wave MI. Women in the increased-risk group had not reported a previous MI, yet 11% had a definite ECG Q-wave MI. Of women reporting hypertension, 35% had ECG evidence of left ventricular hypertrophy, but 58% did not have an abnormal electrocardiogram. Significantly more women with diabetes in the increased-risk and documented CHD cohorts had abnormal electrocardiograms (p <0.01 for the 2 cohorts). Percent abnormal electrocardiograms increased with increasing age (55 to 64, 65 to 74, and ≥75 years, p <0.01) in all cohorts. Angina and coronary artery bypass graft surgery, but not percutaneous coronary intervention, predicted an abnormal electrocardiogram. In conclusion, there were high percentages of normal electrocardiograms in the increased-risk and documented CHD groups of RUTH participants, with substantial discrepancy between MI history and ECG MI documentation, and increasing age was the predominant correlate with an abnormal electrocardiogram in all 3 cohorts.