MORBIDITY IN SCHISTOSOMIASIS JAPONICA IN RELATION TO INTENSITY OF INFECTION - STUDY OF A COMMUNITY IN LEYTE, PHILIPPINES
MORBIDITY IN SCHISTOSOMIASIS JAPONICA IN RELATION TO INTENSITY OF INFECTION - STUDY OF A COMMUNITY IN LEYTE, PHILIPPINES
复制标题
DOI：
10.4269/ajtmh.1980.29.858
复制
发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
HOUSER, HB
中科院分区：
文献类型：
--
作者：
DOMINGO, EO;TIU, E;HOUSER, HB
在圣罗萨村1岁或1岁以上的1098人中，1010人(92%)有完整的寄生虫学检查、病史和体检。日本血吸虫感染率为32.4%。5-9岁年龄段患病率为14%，15-19岁年龄段患病率达57%，30-60岁年龄段下降至30-50%左右。68%的人没有感染，21%的人有轻度感染(1-100个蛋/克粪便)，8%的人有中度感染(101-400)，3%的人有重度感染(>；400)。男性的平均感染强度为186个卵子/克粪便，女性为105个。在总人口中，7%的人描述了一些虚弱，大约7%的人有绞痛性腹痛；这些百分比没有随着感染的存在或强度而改变。有四个人有惊厥史，但他们的粪便中都没有日本血吸虫卵。在体检中，15%的感染者和21%的重度感染者胸骨中线的肝脏肿大等于或大于3厘米，而非感染者中只有8%的人有这种程度的肝脏增大。在男性和女性之间，肝肿大的年龄患病率有显著差异。男性出现肝脏肿大的时间要早得多，这与童年时高水平的产卵量有关。女性直到成年才能获得高卵子产量；随后肝脏肿大的患病率达到顶峰。2.7%的人发现哈克特2级或更大的脾肿大。脾肿大与感染的存在或强度无关。可见，日本血吸虫感染的流行率和强度中等与低发病率有关。与普遍的看法相反，在肯尼亚类似的研究社区中，日本血吸虫病似乎并不是比曼氏血吸虫病更具致病性的感染。
Of the 1098 individuals 1 yr of age or older in the village of Santa Rosa, 1010 (92%) had complete parasitological examinations, histories and physicals. Schistosoma japonicum infection was found in 32.4% of this population. Prevalence was 14% in age group 5-9 yr; it peaked at 57% at age 15-19 yr, and declined to about 30-50% from age 30-60 yr. While 68% of the population was uninfected, 21% had light infections (1-100 eggs/g feces), 8% had moderate infections (101-400), and 3% had heavy infections (> 400). The mean intensity of infection in males was 186 eggs/g feces, and in females 105. Of the overall population, 7% described some weakness and about 7% had colicky abdominal pain; there were no changes in these percentages with either the presence or intensity of infection. Four individuals had a history of convulsions, but none of them had S. japonicum eggs in their feces. On physical examination hepatomegaly equal to or greater than 3 cm in the midsternal line was seen in 15% of the infected population and in 21% of those with heavy infections, while only 8% of uninfected individuals had this degree of liver enlargement. A striking difference in age prevalence of hepatomegaly between males and females was observed. The much earlier onset of liver enlargement in males correlated with high levels of egg output in childhood. Females did not achieve high egg outputs until adulthood; this was later followed by a peak in the prevalence of hepatomegaly. An enlarged spleen of Hackett grade 2 or greater was found in 2.7% of the population. There was no relationship between splenomegaly and the presence or intensity of infection. It appears that S. japonicum infection of a moderate prevalence and intensity was associated with low morbidity. Contrary to general belief, schistosomiasis japonica did not appear to be a significantly more pathogenic infection than schistosomiasis mansoni, as seen in similarly studied communities in Kenya.