Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects
Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects
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DOI：
10.1016/j.nutres.2014.09.007
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发表时间：
2014-10-01
影响因子：
4.5
通讯作者：
Siervo, M.
中科院分区：
文献类型：
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作者：
Jajja, A.;Sutyarjoko, A.;Siervo, M.
虽然补充无机硝酸盐和甜菜根汁与降低收缩压(BP)有关，但这些结果主要是从关注健康年轻人的短期试验中获得的。因此，我们假设口服浓缩甜菜根汁会降低超重老年参与者的收缩压，但在中断甜菜根汁补充1周后，血压的下降不会持续。在3周的时间里，24名参与者被随机分为甜菜根汁浓缩组或黑加仑汁组，补充期为1周(第4周)。在补充阶段和补充后阶段评估收缩压和舒张压的变化。血压测量采用3种不同的方法：(1)门诊静息血压，(2)24小时动态血压监测，(3)家庭监测每日静息血压。前两种方法在基线、3周和4周后应用。在整个研究过程中进行每日测量，21名受试者完成研究(甜菜根/黑加仑=10/11；男性/女性=12/9；年龄=62.0+/-1.4岁；体重指数=30.1+/-1.2 kg/m(2))。3周后，补充甜菜根汁与静息临床血压或24小时动态血压的显著变化无关。相反，甜菜根汁浓缩液在3周后降低了每日的收缩压(-7.3+/-5.9 mm Hg，P=0.02)；然而，在补充中断后(第4周，2.8+/-6.1 mm Hg，P=0.09)，这种效果不再保持。在超重的老年受试者中，补充浓缩甜菜根汁对每日收缩血压有好处，尽管当以24小时动态血压或静息临床血压衡量时，这种影响并不显著。(C)2014 Elsevier Inc.保留所有权利。
Although inorganic nitrate and beetroot juice supplementation are associated with decreased systolic blood pressure (BP), these results have primarily been obtained from short-term trials that focused on healthy young adults. Therefore, we hypothesized that oral supplementation of beetroot juice concentrate would decrease systolic BP in overweight older participants but that the decline in BP would not be sustained after a 1-week interruption of the beetroot juice supplementation. For 3 weeks, 24 participants were randomized to either the beetroot juice concentrate or blackcurrant juice group, with a 1-week postsupplementation phase (week 4). Changes in systolic and diastolic BP were assessed during the supplementation and postsupplementation phases. Blood pressure was measured using 3 different methods: (1) resting clinic BP, (2) 24-hour ambulatory BP monitoring, and (3) home monitoring of daily resting BP. The first 2 methods were applied at baseline and after weeks 3 and 4. Daily measurements were conducted throughout the study, with 21 subjects completing the study (beetroot/blackcurrant = 10/11; male/female = 12/9; age = 62.0 +/- 1.4 years; body mass index = 30.1 +/- 1.2 kg/m(2)). After 3 weeks, beetroot juice supplementation was not associated with significant changes in resting clinic BP or 24-hour ABPM. Conversely, beetroot juice concentrate reduced daily systolic BP after 3 weeks (-7.3 +/- 5.9 mm Hg, P = .02); however, the effect was not maintained after the interruption of the supplementation (week 4, 2.8 +/- 6.1 mm Hg, P = .09). In overweight older subjects, beetroot juice concentrate supplementation was associated with beneficial effects on daily systolic BP, although the effects were not significant when measured by 24-hour ABPM or resting clinic BP. (C) 2014 Elsevier Inc. All rights reserved.