Synthesis of complex unnatural fluorine-containing amino acids.
Synthesis of complex unnatural fluorine-containing amino acids.
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DOI：
10.1016/j.jfluchem.2020.109630
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发表时间：
2020-11
影响因子：
1.9
通讯作者：
Cobb SL
中科院分区：
文献类型：
--
作者：
Brittain WDG;Lloyd CM;Cobb SL
在过去的十年中，氟化氨基酸的合成领域得到了迅速的发展。随着单氟化天然氨基酸衍生物的报道越来越多，研究人员已经将注意力转向开发方法来获得复杂的蛋白质实例。各种反应条件已被用于这一领域，利用更广泛的合成社区，如钯和钯交叉偶联的新进展。此外，新的氟化官能团也被引入氨基酸中，SFX和全氟部分现在在文献中出现得更频繁。本文综述了复杂的非蛋白质氨基酸的合成方法，沿着的氨基酸含有多个氟原子，如CF 3，SF 5和全氟芳香族基团。
The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid derivatives have grown, researchers have turned their attention to develop methodology to access complex proteinogenic examples. A variety of reaction conditions have been employed in this area, exploiting new advances in the wider synthetic community such as photocatalysis and palladium cross-coupling. In addition, novel fluorinated functional groups have also been incorporated into amino acids, with SFX and perfluoro moieties now appearing with more frequency in the literature. This review focuses on synthetic methodology for accessing complex non-proteinogenic amino acids, along with amino acids containing multiple fluorine atoms such as CF3, SF5 and perfluoroaromatic groups.
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DOI：
10.1002/chem.201803144
发表时间：
2018-08-06
期刊：
Chemistry (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
de Bruijn AD;Roelfes G
通讯作者：
Roelfes G
影响因子：
2.7
作者：
Cheerlavancha R;Ahmed A;Leung YC;Lawer A;Liu QQ;Cagnes M;Jang HC;Hu XG;Hunter L
通讯作者：
Hunter L
影响因子：
4.3
作者：
Bykova, Tetiana;Al-Maharik, Nawaf;O'Hagan, David
通讯作者：
O'Hagan, David
影响因子：
1.9
作者：
Bolek, Sylwia;Ignatowska, Jolanta
通讯作者：
Ignatowska, Jolanta
影响因子：
2
作者：
Andrews, PC;Bhaskar, V;McCarthy, TD
通讯作者：
McCarthy, TD