Signature Channels of Excitability no More: L-Type Channels in Immune Cells.
Signature Channels of Excitability no More: L-Type Channels in Immune Cells.
复制标题
兴奋性的签名通道不再：免疫细胞中的L型通道。
DOI：
10.3389/fimmu.2015.00375
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发表时间：
2015
影响因子：
7.3
通讯作者：
Perraud AL
中科院分区：
文献类型：
--
作者：
Davenport B;Li Y;Heizer JW;Schmitz C;Perraud AL
虽然Ca 2+作为一种通用信使的概念已经很好地建立，但人们认为Ca 2+信号的调节机制沿着电兴奋性的路线进行划分。然而，分子生物学和基因组学的最新进展提供了证据，证明非兴奋细胞如免疫细胞也表达广泛而多样的离子通道库，其与最初假设的兴奋细胞的离子通道库没有显著差异。离子通道和转运蛋白参与免疫应答调节的几乎所有方面，从细胞分化和发育到活化，以及效应子功能，如迁移、抗体分泌、吞噬体成熟或杀菌剂的囊泡递送。这包括TRP通道家族成员、电压和Ca 2+门控K+和Na+通道，以及出人意料的电压门控L型Ca 2+通道CaV 1亚家族的成分，最初被认为是特征分子兴奋性。本文提供了一个概述的CaV 1 L-型通道功能在免疫环境中的领域，以及我们获得的研究这些通道在B淋巴细胞的结果。
Although the concept of Ca2+ as a universal messenger is well established, it was assumed that the regulatory mechanisms of Ca2+-signaling were divided along the line of electric excitability. Recent advances in molecular biology and genomics have, however, provided evidence that non-excitable cells such as immunocytes also express a wide and diverse pool of ion channels that does not differ as significantly from that of excitable cells as originally assumed. Ion channels and transporters are involved in virtually all aspects of immune response regulation, from cell differentiation and development to activation, and effector functions such as migration, antibody-secretion, phagosomal maturation, or vesicular delivery of bactericidal agents. This comprises TRP channel family members, voltage- and Ca2+-gated K+- and Na+-channels, as well as unexpectedly, components of the CaV1-subfamily of voltage-gated L-type Ca2+-channels, originally thought to be signature molecules of excitability. This article provides an overview of recent observations made in the field of CaV1 L-type channel function in the immune context, as well as presents results we obtained studying these channels in B-lymphocytes.