Trends in sarcoidosis mortality rate in Japan from 2001 to 2020: A population-based study
Trends in sarcoidosis mortality rate in Japan from 2001 to 2020: A population-based study
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DOI：
10.1016/j.rmed.2022.106828
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发表时间：
2022-03-26
影响因子：
4.3
通讯作者：
Otsuka, Fumio
中科院分区：
文献类型：
--
作者：
Harada, Ko;Hagiya, Hideharu;Otsuka, Fumio
背景：结节病的死亡率逐年上升，这增加了医疗负担。虽然在老龄化社会的结节病死亡率的流行病学研究是必不可少的，没有发表自1989年在Japanes.Methods：我们的目的是调查的趋势，粗和年龄调整结节病相关的死亡率每100万人口在日本从2001年至2020年使用国家死亡证明数据年龄超过50岁的老年人。数据进行了分析，使用joinpoint回归模型估计长期趋势和平均年百分比变化（AAPC）。结果：从2001年至2020年，日本共记录了3094例结节病相关死亡;女性占65.3%，女性：男性比例为1.89。近80%的死亡者年龄在65岁以上，其中32%的死亡者年龄在80岁以上。80岁以上人口的粗死亡率趋势明显增加，男性从每100万人0.81人增加到9.68人，女性从每100万人2.38人增加到12.87人。在研究期间，结节病的年龄校正死亡率增加了2.46倍，AAPC为5.1%.Conclusions：本研究显示日本结节病相关死亡在过去20年中显著增加，尤其是在女性占优势的老年人群中。鉴于老年人群的死亡率和易感性不断上升，结节病将需要卫生保健提供者在多学科方法方面给予更多关注，以满足老年人群的特殊需求。
Background: The sarcoidosis mortality rate has increased over the years, which contributes to the health care burden. Although epidemiological studies of sarcoidosis mortality in aging societies are essential, none have been published since 1989 in Japan.Methods: We aimed to investigate the trends in crude and age-adjusted sarcoidosis-associated mortality rates per 1,000,000 population in Japan from 2001 to 2020 using national death certificate data among older adults aged over 50 years. The data were analysed using the joinpoint regression models to estimate long-term trends and average annual percentage changes (AAPCs).Results: A total of 3094 sarcoidosis-associated deaths were recorded from 2001 to 2020 in Japan; women constituted 65.3% of these, with a female:male ratio of 1.89. Nearly 80% of deaths were over the age of 65 years, of which 32% were over the age of 80 years. The trend in crude mortality of those aged >= 80 years markedly increased from 0.81 to 9.68 per 1,000,000 population in men and from 2.38 to 12.87 in women, respectively. The overall age-adjusted sarcoidosis mortality rate increased 2.46-fold during the study period, with an AAPC of 5.1%.Conclusions: This study revealed that sarcoidosis-associated deaths in Japan have significantly increased over the past two decades, especially among the older population with a female predominance. Given the rising mortality rate and susceptibility of the older population, sarcoidosis will require more attention from health care providers in terms of a multidisciplinary approach to address the specific needs of the older population.