EFFECT OF ISOENERGETIC INTAKE OF 3 OR 9 MEALS ON PLASMA-LIPOPROTEINS AND GLUCOSE-METABOLISM
EFFECT OF ISOENERGETIC INTAKE OF 3 OR 9 MEALS ON PLASMA-LIPOPROTEINS AND GLUCOSE-METABOLISM
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DOI：
10.1093/ajcn/57.3.446
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发表时间：
1993-03-01
影响因子：
7.1
通讯作者：
MANN, J
中科院分区：
文献类型：
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作者：
ARNOLD, LM;BALL, MJ;MANN, J
为了研究进餐频率对血脂和碳水化合物代谢的影响，19名正常胆固醇血症自由生活的健康男性和女性按随机顺序每天进食3餐或9餐，每人2wk。常量营养素摄入量无显著差异。与每天三餐饮食相比，一天九餐可使空腹血浆总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇分别降低6.5%(P<；0.005)、8.1%(P<；0.005)和4.1%(P<；0.05)。体重、空腹甘油三酯、载脂蛋白A-I和B以及低密度脂蛋白-高密度脂蛋白胆固醇比率以及24小时尿C肽-肌酐比率和胰岛素-葡萄糖对葡萄糖负荷的反应在两种饮食中没有差别。餐后3h以上的胰岛素-血糖曲线在9餐中较为平坦，但曲线下面积无显著差异。增加膳食频率，同时保持恒定的营养摄入量，在正常血脂的自由生活受试者中，低密度脂蛋白胆固醇的下降幅度很小，但却很明显。
To investigate the effects of meal frequency on plasma lipid and carbohydrate metabolism, 19 healthy normocholesterolemic free-living men and women consumed their usual diet as three or nine meals per day in random order for 2 wk each. There was no significant difference in macronutrient intake. Compared with the three-meal/d diet, nine meals per day reduced fasting plasma total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol by 6.5% (P < 0.005), 8.1% (P < 0.005), and 4.1% (P < 0.05), respectively. Body weight, fasting triglycerides, apolipoproteins A-I and B, and the LDL-HDL cholesterol ratios were not different for the two diets, as were 24-h urinary C peptide-creatinine ratios and insulin-glucose response to a glucose load. The insulin-glucose curve measured over 3 h in the evening after the evening meal was flatter for the nine meals, but the areas under the curves were not significantly different. Increasing meal frequency while maintaining a constant nutrient intake produces a small but significant decrease in LDL cholesterol in normolipidemic free-living subjects.