Assessment of Biomarkers in asbestos-exposed workers as indicators of cancer risk
Assessment of Biomarkers in asbestos-exposed workers as indicators of cancer risk
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DOI：
10.1016/j.mrgentox.2008.06.011
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发表时间：
2008-08-01
影响因子：
1.9
通讯作者：
Santarelli, Lory
中科院分区：
文献类型：
--
作者：
Amati, Monica;Tomasetti, Marco;Santarelli, Lory
流行病学研究表明，恶性间皮瘤和肺癌的死亡率随着石棉累积暴露量的增加而增加。为了研究肿瘤相关生物标志物是否有助于评估暴露于石棉的人群的致癌风险，DNA加合物8-羟基-2 '-脱氧鸟苷（8 OHdG）、白细胞介素-6（IL-6）、血小板衍生生长因子（PDGF-BB）、肝细胞生长因子（HGF）、碱性成纤维细胞生长因子（bFGF）、对在工作场所不同程度地接触石棉纤维的一组工人的血管内皮生长因子（VEGF β）和可溶性间皮素相关肽（SMRPs）进行了分析。为了记录未暴露人群中的生物标志物水平，招募了54名年龄匹配的受试者。共有119名受试者的职业暴露于石棉的历史进行了临床检查，并接受了训练有素的人员进行了采访，回答有关石棉暴露，吸烟和职业任务的持续时间的详细问卷调查。根据职业任务，石棉暴露受试者的石棉累积剂量进行了分析，并与生物标志物进行了评估。在职业组别中，维修工人、喉管安装工及电工接触石棉纤维的累积剂量较高。石棉暴露显著增加了DNA中8 OHdG的稳态含量。80 HdG和IL-6水平升高最好地反映了高水平的SMRP，这与细胞转化有关。严重暴露于石棉的受试者[>60（ff/cm（3））x年]也显示出较高水平的血管生成因子。血管生成生物标志物与特定间皮瘤生物标志物（如SMRPs）的组合可用于密切监测有石棉暴露史的工人。(C)2008 Elsevier B. V.保留所有权利。
Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos. To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to asbestos, the DNA adduct 8-hydroxy-2'-deoxyguanosine (8OHdG), interleukine-6 (IL-6), platelet-derived growth factor (PDGF-BB), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF beta) and soluble mesothelin-related peptides (SMRPs) were analysed in a cohort of workers differently exposed to asbestos fibres at the workplace. To document biomarker levels in an unexposed population, 54 age-matched subjects were enrolled. A total of 119 subjects with a history of occupational exposure to asbestos underwent clinical examination and were interviewed by trained personnel, responding to a detailed questionnaire related to duration of asbestos exposure, smoking, and occupational task. According to the occupational tasks, asbestos-exposed subjects were analysed for their asbestos cumulative dose and the association with the biomarkers was evaluated. Among the occupational groups, maintenance workers, pipe fitters and electricians were exposed to a higher cumulative dose of asbestos fibres. Exposure to asbestos significantly increased the steady-state content of 8OHdG in DNA. Elevated levels of 80HdG and IL-6 best reflected a high level of SMRPs, which is related to cell transformation. Subjects heavily exposed to asbestos [>60 (ff/cm(3)) x years] showed also a higher level of angiogenic factors. A combination of angiogenic biomarkers with a specific mesothelioma-biomarker such as SMRPs Could be used for close surveillance of workers with a history of asbestos exposure. (C) 2008 Elsevier B.V. All rights reserved.