Clinical and prognostic value of elevated CA125 levels in patients with coronary heart disease
Clinical and prognostic value of elevated CA125 levels in patients with coronary heart disease
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DOI：
10.1007/s00059-014-4109-y
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发表时间：
2015-06-01
期刊：
影响因子：
1.7
通讯作者：
Zhenyue, C.
中科院分区：
文献类型：
--
作者：
Rong, X.;Yunke, Z.;Zhenyue, C.
目标。本研究旨在探讨血清糖类抗原125(CA125)水平与冠心病(CHD)的关系，并评价其在冠心病患者近期预后中的作用。根据临床表现和冠状动脉造影结果分为急性冠脉综合征组(n=40)、稳定型冠心病组(n=)和对照组(n=46)。分别于入院时和入院后第5天采集空腹血样，测定血清CA125等生化指标。两个冠心病亚组入院时血清CA125水平均显著高于对照组(冠心病组P<；0.01，冠心病组稳定组P<；0.05)。入院第5天与入院第5天比较，差异仍有统计学意义(P均<0.05)；入院第5天，急性冠心病组CA125水平高于冠心病稳定期组(P<0.05)。CA125水平与脑利钠肽原(ProBNP)、左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)呈正相关，与左心室射血分数(LVEF)呈负相关。与其他患者相比，在3个月的随访中，发生心力衰竭事件的患者入院时血清CA125水平显著升高(p=0.037)。入院第5天CA125值明显高于其他患者(p=0.002)。冠心病患者血清CA125水平与心功能显著相关。冠心病发作后持续升高的血清CA125水平有助于预测冠心病患者发生心力衰竭事件的短期风险。
Objective. The aims of this study were to explore the association between serum level of carbohydrate antigen 125 (CA125) and coronary heart disease (CHD), and to evaluate its role in the short-term prognosis of CHD patients.Methods. A total of 150 patients were enrolled in the study and divided into an acute coronary syndrome (ACS) group (n= 40), a stable CHD group (n= 64), and a control group (n= 46) according to clinical presentation and angiographic results. Fasting blood samples were collected at two time points, on admission and on the fifth day after hospitalization for the measurement of serum CA125 and other biomarkers.Results. Serum CA125 levels in both CHD subgroups were significantly higher than the control group on admission (p< 0.01 for the ACS group and p< 0.05 for the stable CHD group). The differences remained significant on the fifth day after hospitalization (both p< 0.05), and the CA125 levels in the ACS group were higher than in the stable CHD group on the fifth day (p< 0.05). The CA125 levels were positively correlated with pro-brain natriuretic peptide (pro-BNP), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), and negatively correlated with left ventricular ejection fraction (LVEF). Compared with the other patients, serum CA125 levels on admission were significantly elevated in the patients who suffered from heart failure events during a 3-month follow-up (p= 0.037). The CA125 level on the fifth day of hospitalization in these patients stayed at a significantly higher level than the other patients (p= 0.002).Conclusions. The serum CA125 levels were significantly related with cardiac function in CHD patients. Serum CA125 levels that remain elevated after CHD onset could be helpful for predicting the short-term risk of heart failure events in CHD patients.