LUNG-CANCER MORTALITY AMONG A COHORT OF MALE CHROMATE PIGMENT WORKERS IN JAPAN
LUNG-CANCER MORTALITY AMONG A COHORT OF MALE CHROMATE PIGMENT WORKERS IN JAPAN
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DOI：
10.1093/ije/22.1.16
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发表时间：
1993-02-01
影响因子：
7.7
通讯作者：
YAMAGUCHI, S
中科院分区：
文献类型：
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作者：
KANO, K;HORIKAWA, M;YAMAGUCHI, S
1975年，日本的五家铬酸盐颜料制造商在一项关于铬酸盐致癌作用的研究中受到了调查。这些公司生产铬酸铅、铬酸锌、钼酸橙和/或铬酸锶。目前的研究涵盖了1950年至1975年间从事铬酸盐颜料生产至少一年的666名工人。对这些工人进行了15-40年的跟踪调查，直到1989年。以前的许多报告都发现，从事铬酸盐颜料和铬酸盐化学品制造的工人患肺癌的风险过高。在目前的研究中，受试者根据工作年限、观察年限、公司特征、从事时间最长的工作类型以及参与铬酸锌制造进行分类。死亡率用人年法与所有日本男性的死亡率进行比较。接触途径主要是通过呼吸系统吸入。没有一项结果显示，在日本从事铬酸盐颜料生产的工人中，有统计学意义的差异表明罹患恶性肿瘤，尤其是肺癌的风险过高。
In 1975, five manufacturers of chromate pigment in Japan were examined in a study of the carcinogenicity of chromates. These companies were producing lead chromate, zinc chromate, molybdate orange and/or strontium chromate. The current study covers a cohort of 666 workers involved in the manufacture of chromate pigment for at least 1 year between 1950 and 1975. The workers were followed up for 15-40 years, until 1989. Many previous reports have found an excess lung cancer risk among workers involved in the manufacture of chromate pigments and chromate chemicals. In the current study, subjects were classified on the basis of years worked, years of observation, characteristics of company, type of work engaged in for the longest period of time, and involvement in the manufacture of zinc chromate. Mortality was compared with that of all Japanese males by means of the person-year method. The route of exposure was primarily inhalation through the respiratory system. None of the results showed statistically significant differences that would suggest an excess risk for malignant neoplasms, particularly lung cancer, among workers engaged in the manufacture of chromate pigment in Japan.