Awareness of dysgeusia and gustatory tests in patients undergoing chemotherapy for breast cancer
Awareness of dysgeusia and gustatory tests in patients undergoing chemotherapy for breast cancer
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DOI：
10.1007/s00520-018-4256-4
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发表时间：
2018-11-01
影响因子：
3.1
通讯作者：
Eguchi, Susumu
中科院分区：
文献类型：
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作者：
Kuba, Sayaka;Fujiyama, Rie;Eguchi, Susumu
目的分析乳腺癌（BC）化疗患者味觉检查异常的发生率。方法选取43例接受化疗的BC患者和38例未接受化疗的BC患者作为对照组。进行了两种味觉测试：一种是检测四种基本味觉刺激阈值的灌注法，另一种是测量舌头前三分之二（颅神经VII）和后三分之一（颅神经IX）的电刺激感知阈值的电测法。比较化疗组与对照组、化疗组有与无厌食意识患者两项味觉检查结果及临床病理因素。结果化疗组有19例（44%）患者意识到咽水困难，8例（19%）患者意识到咽水不足。虽然化疗组出现吸虫病的患者多于对照组，但两项味觉测试结果无显著差异。有发音困难意识的患者在颅神经IX处的阈值高于无发音困难意识的患者；灌注法在缺氧方面无显著差异。事实上，74%（14/19）有读写障碍意识的患者能够准确识别四种味道。颅7神经滴注法和电刺激法观察到相似的结果。结论约有一半的化疗患者有发音障碍的意识，81%（35/43）的患者能准确识别四种基本味道。
Purpose We analyzed the prevalence of gustatory test abnormalities in breast cancer (BC) patients undergoing chemotherapy.Methods We enrolled 43 BC patients undergoing chemotherapy and 38 BC patients who had never undergone chemotherapy (control group). Two gustatory tests were conducted: an instillation method examining the threshold for four basic taste stimuli and an electrogustometry method measuring the threshold for perception with electric stimulation at the front two-thirds of the tongue (cranial nerve VII) and at the back third of the tongue (cranial nerve IX). The results of the two gustatory tests and clinicopathological factors were compared between the chemotherapy and control groups and between patients with and without awareness of dysgeusia in the chemotherapy group.Results In the chemotherapy group, 19 (44%) patients were aware of dysgeusia and 8 (19%) had hypogeusia using the instillation method. Although more patients had parageusia in the chemotherapy than control group, no significant differences in the results of the two gustatory tests were observed. Patients with dysgeusia awareness had a higher threshold at cranial nerve IX using the electrogustometry method than those without dysgeusia awareness; no significant differences in hypogeusia were observed using the instillation method. In fact, 74% (14/19) of patients with dysgeusia awareness could identify the four tastes accurately using the instillation method. Similar results were observed for the instillation and electrogustometry methods at cranial nerve VII.Conclusions While approximately half of the chemotherapy patients were aware of dysgeusia, 81% (35/43) of them could accurately identify the four basic tastes using the instillation method.