Models for chromatin remodeling: a critical comparison.
Models for chromatin remodeling: a critical comparison.
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染色质重塑模型：关键比较。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Thomas D. Yager
中科院分区：
文献类型：
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作者：
K. Holde;Thomas D. Yager
在许多情况下，核小体重塑已被证明涉及DNA上核小体的顺式置换。这一过程似乎与核小体沿着DNA的随机扩散相似，但重塑过程是单向的，并且依赖于ATP。几年前，我们开发了一个核小体迁移的模型，基于核小体DNA内“扭曲缺陷”的扩散。这已经被修改成一个模型，结合ATP依赖性缺陷的产生，并可以解释许多关于重塑的观察。然而，近年来的一些实验研究对扭曲扩散模型的适用性提出了质疑，似乎倾向于“爬行”模型。我们在此讨论这些问题，并提出解决方案。
Nucleosome remodeling has been shown, in many cases, to involve cis displacement of nucleosomes on the DNA. This process seems similar to the long-recognized random diffusion of nucleosomes along DNA, but the remodeling process is unidirectional and ATP dependent. Several years ago, we developed a model for nucleosome migration, based on the diffusion of "twist-defects" within the nucleosomal DNA. This has been modified into a model that incorporates ATP-dependent defect generation, and can account for many observations concerning remodeling. However, certain experimental studies in recent years have cast doubt on the applicability of the twist-diffusion model for remodeling, and seem to favor instead a "reptation" model. We discuss herein these problems and propose a resolution.
影响因子：
5.6
作者：
SHORE, D;BALDWIN, RL
通讯作者：
BALDWIN, RL