Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements
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产前接触全氟烷基和多氟烷基物质与出生结果：重复测量的纵向队列
DOI：
10.1016/j.chemosphere.2020.128899
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发表时间：
2021-01-16
期刊：
影响因子：
8.8
通讯作者：
Tian, Ying
中科院分区：
文献类型：
--
作者：
Chen, Lin;Tong, Chuanliang;Tian, Ying
背景资料：目的：探讨妊娠期全氟烷基和多氟烷基物质（PFAS）的浓度变化规律，寻找PFAS对胎儿毒性作用的敏感窗口期。我们采用高效液相色谱/串联质谱法（HPL-CMS/MS）定量测定了妊娠三个月的母体血浆和分娩时脐带血中的10种PFAS。多元线性回归分析PFAS与出生结局的关系，包括出生体重，出生身长，头围。结果：大多数PFAS的浓度在怀孕期间大幅下降。PFOS、PFNA、PFDA、PFUA和PFDoA仅在孕早期与出生身长呈负相关。出生身长随PFOS、PFNA、PFDA、PFUS和PFDoA浓度对数单位增加而变化的系数和95%置信区间（CI）为-0.27 cm（-0.51，-0.02）、-0.34 cm（-0.65，-0.03）、-0.27 cm（-0.53，-0.01）、-0.29 cm（-0.58，-0.01）和-0.54 cm（-1.00，-0.08）。仅在雌性胎仔中观察到这些影响。PFAS与出生体重、头围无相关性。结论：妊娠期母体血中PFAS浓度呈下降趋势。有几个PFAS和出生长度之间的负相关。暴露的敏感窗口似乎是前三个月。这种关联对于女性胎儿来说更强。(C)2020爱思唯尔有限公司保留所有权利。
Background: Previous studies on perfluoroalkyl and polyfluoroalkyl substances (PFAS) showed inconsistent results when biological samples were collected in different time of pregnancy.Objectives: To describe the change of PFAS concentration during pregnancy and to identify a sensitive window for adverse effects of PFAS on the fetus.Methods: A total of 255 pregnant women were selected from the Shanghai Birth Cohort (SBC). We quantified 10 PFAS with high-performance liquid chromatography/tandem mass spectrometry (HPL-CMS/MS) in maternal plasma at three trimesters and cord blood at delivery. Multiple linear regression analyses were used to analyze the association between PFAS and birth outcomes, including birth weight, birth length, and head circumference.Results: The concentrations of most PFAS declined substantially during pregnancy. PFOS, PFNA, PFDA, PFUA and PFDoA were negatively related to birth length only in the first trimester. The coefficients and 95% confidence intervals (CI) of birth length change with a log-unit increase in PFOS, PFNA, PFDA, PFUS and PFDoA concentrations were -0.27 cm (-0.51, -0.02), -0.34 cm (-0.65, -0.03), -0.27 cm (-0.53, -0.01), -0.29 cm (-0.58, -0.01), and -0.54 cm (-1.00, -0.08), respectively. The effects were only observed for female fetuses. No association between PFAS and birth weight or head circumference was observed.Conclusion: The concentrations of most PFAS in the maternal circulation declined during pregnancy. There were negative associations between several PFAS and birth length. The sensitive window of exposure appeared to be the first trimester. The association was stronger for female fetuses. (C) 2020 Elsevier Ltd. All rights reserved.