Rupture of Reissner's membrane during acute endolymphatic hydrops in the guinea pig: a model for Meniere's disease?
Rupture of Reissner's membrane during acute endolymphatic hydrops in the guinea pig: a model for Meniere's disease?
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DOI：
10.1080/00016480600621722
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发表时间：
2006-10-01
影响因子：
1.4
通讯作者：
Albers, F. W. J.
中科院分区：
文献类型：
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作者：
Valk, W. L.;Wit, H. P.;Albers, F. W. J.
结论。在破坏性急性内淋巴积水期间，耳蜗功能的变化相对较小。这可能与内淋巴积液是内耳内稳态紊乱的标志而不是梅尼埃病临床症状的原因的假设一致。目标。破坏性急性内淋巴积液诱导过程中的耳蜗功能评估。材料和方法。以50nL/S的速度重复注射0.5亩L人工内淋巴时，在豚鼠记录到2f(1)-f(2)和f(2)-f(1)耳蜗微音失真产物和2f(1)-f(2)失真产物耳声发射。结果。当L注射2.5-3.5亩人工内淋巴时，内耳发生了一场‘大灾难’。然后发现Reissner膜破裂，最常见的是在耳蜗尖转角。此破裂对耳蜗内电位影响不大，而2f(1)-f(2)DPOAE波幅显著降低。在破裂前的每次注射中，2f(1)-f(2)和f(2)-f(1)CMDP波幅均增加。破裂后，f(2)-f(1)CMDP波幅在每次注射过程中下降，可能是由于耳蜗换能器操作点位置的移位所致。
Conclusion. The changes in cochlear function during a destructive acute endolymphatic hydrops were relatively small. This might be consistent with the hypothesis that an endolymphatic hydrops is a marker of disordered inner ear homeostasis rather than the cause of the clinical symptoms of Meniere's disease. Objective. Assessment of cochlear function during induction of a destructive acute endolymphatic hydrops. Materials and methods. During repetitive microinjections of 0.5 mu l of artificial endolymph at a rate of 50 nl/s the 2f(1) - f(2) and f(2) - f(1) cochlear microphonics distortion products (CMDP) and 2f(1) - f(2) distortion products otoacoustic emissions (DPOAE) were recorded in the guinea pig. Results. A 'catastrophe' occurred in the inner ear when 2.5 - 3.5 mu l of artificial endolymph was injected. A rupture of Reissner's membrane was then found, most often in the apical turn of the cochlea. This rupture had only minor effects on the endocochlear potential, whereas it caused a marked decrease in 2f(1) - f(2) DPOAE amplitude. The 2f(1) - f(2) and f(2) - f(1) CMDP amplitude increased during each injection prior to the rupture. After the rupture the f(2) - f(1) CMDP amplitude decreased during each injection, possibly due to a shift of the cochlear transducer operating point position.