Resveratrol supplementation reduces pain experience by postmenopausal women
Resveratrol supplementation reduces pain experience by postmenopausal women
复制标题
补充白藜芦醇可减轻绝经后女性的疼痛体验
作者：
R. Wong;H. Evans;Peter R C Howe
目的：疼痛是绝经后妇女常见的主诉。据推测，绝经期雌激素下降引起的血管功能障碍在退化性关节疾病（即年龄相关性骨关节炎）的发生和发展中起着关键作用。我们评估了补充白藜芦醇（一种植物雌激素）是否可以改善健康状况，例如绝经后妇女通常经历的慢性疼痛。方法：对80名健康绝经后妇女进行为期14周的随机、双盲、安慰剂对照干预，给予反式白藜芦醇75 mg，每日2次。 在基线和治疗结束时，通过简表-36评估幸福感的各个方面，包括疼痛、更年期症状、睡眠质量、抑郁症状、情绪状态和生活质量。对评分量表取平均值，以提供代表总体幸福感的综合评分。脑血管舒张剂对高碳酸血症的反应性也被评估为脑血管功能的替代标志物。结果如下：与安慰剂治疗相比，补充白藜芦醇后疼痛明显减轻，总体健康状况有所改善。这两种益处，包括生活质量的测量，都与脑血管功能的改善相关。结论：我们的初步研究结果表明，白藜芦醇治疗，以减少慢性疼痛的年龄相关性骨关节炎的潜力。白藜芦醇的消费也可能提高绝经后妇女的幸福感。需要进一步研究以阐明潜在的机制。
Objective: Pain is a common complaint among postmenopausal women. It has been postulated that vascular dysfunction caused by estrogen decline at menopause plays a key role in the initiation and progression of degradative joint disease, namely age-related osteoarthritis. We evaluated whether supplementation with resveratrol, a phytoestrogen, could improve aspects of well-being such as chronic pain that is commonly experienced by postmenopausal women. Methods: A 14-week randomized, double-blind, placebo-controlled intervention with trans-resveratrol (75 mg, twice daily) was conducted in 80 healthy postmenopausal women. Aspects of well-being, including pain, menopausal symptoms, sleep quality, depressive symptoms, mood states, and quality of life were assessed by Short form-36 at baseline and at the end of treatment. Rating scales were averaged to provide a composite score representing overall well-being. Cerebral vasodilator responsiveness to hypercapnia was also assessed as a surrogate marker for cerebrovascular function. Results: Compared with placebo treatment, there was a significant reduction in pain and an improvement in total well-being after resveratrol supplementation. Both benefits, including measures of quality of life, correlated with improvements in cerebrovascular function. Conclusions: Our preliminary findings indicate potential for resveratrol treatment to reduce chronic pain in age-related osteoarthritis. Resveratrol consumption may also boost perceptions of well-being in postmenopausal women. Further investigation to elucidate underlying mechanisms is warranted.
影响因子：
5.8
作者：
Ghanim, Husam;Sia, Chang Ling;Dandona, Paresh
通讯作者：
Dandona, Paresh