Opinion - Yeast as a model system for anticancer drug discovery
Opinion - Yeast as a model system for anticancer drug discovery
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DOI：
10.1038/nrc1372
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发表时间：
2004-06-01
影响因子：
78.5
通讯作者：
Bedalov, A
中科院分区：
文献类型：
--
作者：
Simon, JA;Bedalov, A
酵母作为模式生物被广泛应用于真核细胞生物学的许多方面。它结合了其细胞过程和哺乳动物细胞过程之间的高度保守，以及简单的生长要求、快速的细胞分裂、易于遗传操作和丰富的用于全基因组生物功能分析的实验工具等优势。如何将这些优势用于抗癌药物的研发？
Yeast is widely used as a model organism for investigating many aspects of eukaryotic cell biology. It combines a high level of conservation between its cellular processes and those of mammalian cells with advantages such as simple growth requirements, rapid cell division, ease of genetic manipulation and a wealth of experimental tools for genome-wide analysis of biological functions. How can these advantages be put to use in anticancer drug discovery?