Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort.
Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort.
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DOI：
10.1289/ehp243
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发表时间：
2016-10
影响因子：
10.4
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Nachman RM;Mao G;Zhang X;Hong X;Chen Z;Soria CS;He H;Wang G;Caruso D;Pearson C;Biswal S;Zuckerman B;Wills-Karp M;Wang X
产前暴露于环境PM2.5（即空气动力学直径≤2.5 μm的细颗粒物）与早产和低出生体重有关。产前PM2.5暴露与宫内炎症（IUI）之间的关系尚未得到评估，宫内炎症是早产和神经发育结局的重要危险因素。我们的目的是调查波士顿出生队列（主要是城市低收入少数群体）中孕产妇暴露于PM2.5与IUI之间的关系。该分析包括波士顿出生队列中的5059对母婴。根据产时发热和胎盘病理评估IUI。PM2.5暴露量是根据美国环保署空气质量系统的数据进行分配的。优势比（OR）和95%置信区间（CI）量化了孕前和怀孕各时期母体PM2.5暴露与IUI的关系。将PM2.5暴露的最高四分位数与最低四分位数进行比较，多重校正与IUI的关联在考虑的所有暴露期间都是显著的，包括受孕前3个月（OR = 1.52; 95% CI: 1.22, 1.89）、妊娠早期（OR = 1.93; 95% CI: 1.55, 2.40）、妊娠中期（OR = 1.67; 95% CI: 1.35, 2.08）、妊娠晚期（OR = 1.53; 95% CI: 1.24, 1.90）和整个妊娠（OR = 1.92; 95% CI: 1.55, 2.37）。尽管暴露量相对较低，但我们的研究结果表明，孕前和怀孕期间PM2.5暴露与IUI之间存在单调的正相关关系。IUI可能是评估PM2.5暴露对发育中的胎儿早期生物学影响的敏感生物标志物。Nachman RM，毛刚，张鑫，洪鑫，陈忠，Soria CS，何宏，王刚，Caruso D, Pearson C, Biswal S, Zuckerman B, will - karp M，王鑫。2016。孕前和怀孕特定时期的宫内炎症和母体暴露于环境PM2.5：波士顿出生队列。环境健康展望124:1608-1615；http://dx.doi.org/10.1289/EHP243
Prenatal exposure to ambient PM2.5, (i.e., fine particulate matter, aerodynamic diameter ≤ 2.5 μm) has been associated with preterm birth and low birth weight. The association between prenatal PM2.5 exposure and intrauterine inflammation (IUI), an important risk factor for preterm birth and neurodevelopmental outcomes, has not been evaluated. We aimed to investigate the association between maternal exposure to PM2.5 and IUI in the Boston Birth Cohort, a predominantly urban low-income minority population. This analysis included 5,059 mother–infant pairs in the Boston Birth Cohort. IUI was assessed based on intrapartum fever and placenta pathology. PM2.5 exposure was assigned using data from the U.S. EPA’s Air Quality System. Odds ratios (OR) and 95% confidence intervals (CI) quantified the association of maternal PM2.5 exposure during preconception and various periods of pregnancy with IUI. Comparing the highest with the lowest PM2.5 exposure quartiles, the multi-adjusted association with IUI was significant for all exposure periods considered, including 3 months before conception (OR = 1.52; 95% CI: 1.22, 1.89), first trimester (OR = 1.93; 95% CI: 1.55, 2.40), second trimester (OR = 1.67; 95% CI: 1.35, 2.08), third trimester (OR = 1.53; 95% CI: 1.24, 1.90), and whole pregnancy (OR = 1.92; 95% CI: 1.55, 2.37). Despite relatively low exposures, our results suggest a monotonic positive relationship between PM2.5 exposure during preconception and pregnancy and IUI. IUI may be a sensitive biomarker for assessing early biological effect of PM2.5 exposure on the developing fetus. Nachman RM, Mao G, Zhang X, Hong X, Chen Z, Soria CS, He H, Wang G, Caruso D, Pearson C, Biswal S, Zuckerman B, Wills-Karp M, Wang X. 2016. Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston Birth Cohort. Environ Health Perspect 124:1608–1615; http://dx.doi.org/10.1289/EHP243