Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
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DOI：
10.1080/13803390903521018
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Caccappolo, Elise
中科院分区：
文献类型：
--
作者：
Alcalay, Roy N.;Mejia-Santana, Helen;Caccappolo, Elise
虽然对早发性帕金森病（EOPD）认知障碍的危险因素知之甚少，但尸检研究表明，痴呆与路易体（DLB）和葡萄糖脑苷酶（GBA）突变之间存在关联。我们比较了699名EOPD参与者的迷你精神状态检查（MMSE）表现和自我报告的认知障碍，这些参与者的帕金（PRKN）、富亮氨酸重复激酶2 （LRRK2）和GBA基因突变分型。采用Logistic回归评估认知障碍报告与MMSE评分之间的关系，以及大湾区组成员身份与自我报告的认知障碍和MMSE之间的关系。GBA携带者报告了更多的损伤，但MMSE表现在遗传组之间没有差异。需要详细的神经心理学测试来探索认知障碍与GBA突变之间的关系。
While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.