A generalized target theory and its applications.
A generalized target theory and its applications.
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广义目标理论及其应用
DOI：
10.1038/srep14568
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发表时间：
2015-09-28
影响因子：
4.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhao L;Mi D;Hu B;Sun Y
放射生物学模型在放射治疗和辐射风险评估中具有重要意义。然而，大多数应用模型都有自己的应用范围。本文利用模糊数学中的Yager否定算子对传统靶理论中“命中”与“存活”之间的关系进行了推广，提出了一个综合考虑细胞修复效应和辐射间接效应的辐射诱导细胞失活的广义靶模型。模型的模拟结果以及对“细胞内靶点数目”和“每个靶点的命中次数”的重新思考表明，在现有的理论框架下，只需要研究广义单命中单靶（GSHST）。分析表明，GSHST模型在低剂量区和高剂量区可分别简化为线性二次模型和多靶模型。拟合结果表明，GSHST模型与通常的实验观测结果吻合较好。此外，该模型还可用于预测细胞修复能力、放射敏感性、靶区大小，特别是生物学有效剂量，为临床治疗提供依据。
Different radiobiological models have been proposed to estimate the cell-killing effects, which are very important in radiotherapy and radiation risk assessment. However, most applied models have their own scopes of application. In this work, by generalizing the relationship between “hit” and “survival” in traditional target theory with Yager negation operator in Fuzzy mathematics, we propose a generalized target model of radiation-induced cell inactivation that takes into account both cellular repair effects and indirect effects of radiation. The simulation results of the model and the rethinking of “the number of targets in a cell” and “the number of hits per target” suggest that it is only necessary to investigate the generalized single-hit single-target (GSHST) in the present theoretical frame. Analysis shows that the GSHST model can be reduced to the linear quadratic model and multitarget model in the low-dose and high-dose regions, respectively. The fitting results show that the GSHST model agrees well with the usual experimental observations. In addition, the present model can be used to effectively predict cellular repair capacity, radiosensitivity, target size, especially the biologically effective dose for the treatment planning in clinical applications.