Reliability of a patient-reported outcome measure in schizophrenia: Results from back-to-back self-ratings
Reliability of a patient-reported outcome measure in schizophrenia: Results from back-to-back self-ratings
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DOI：
10.1016/j.psychres.2016.07.055
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发表时间：
2016-10-30
影响因子：
11.3
通讯作者：
Remington, Gary
中科院分区：
文献类型：
--
作者：
Takeuchi, Hiroyoshi;Fervaha, Gagan;Remington, Gary
本研究旨在评估患者执行患者报告结果（PRO）测量（即自评量表）的能力，并研究其与包括认知在内的临床特征的关系。对50例精神分裂症患者进行2次抗精神病药简易量表主观幸福感评分；第二次评分在他们完成第一次评分后立即开始，以尽量减少评分之间的差距。同时进行阳性和阴性症状量表（PANSS）和简短神经认知评估（BNA）。两种评分的SWNS总分与各单项得分的相关性均较高(r(s)=0.94, r(s)=0.60 ~ 0.84)；然而，在20项中的16项（80%）中，有5名或更多患者（即>= 10%）表现出> 1分的评分差异。SWNS总分差异与年龄、受教育程度、病程、抗精神病药物剂量、精神病理、认知等临床特征均无显著相关性。相比之下，具有> 1分评分差异的项目数量与紊乱症状和总体严重程度（r(s) = 0.29）以及工作记忆和整体认知(r（s) = -0.41和r(s) = -0.40）显著相关。这些研究结果表明，对于有明显紊乱和认知障碍的精神分裂症患者，应谨慎解释PROs。2016爱思唯尔爱尔兰有限公司版权所有。
This study aimed to assess patient's capacity to perform a patient-reported outcome (PRO) measure (i.e., a self-rating scale) and examine its relationship with clinical characteristics including cognition. Fifty patients with schizophrenia were asked to rate the Subjective Well-being under Neuroleptics scale Short form (SWNS) twice; the second rating was started immediately after they completed the first to minimize the gap between ratings. At the same time, the Positive and Negative Symptoms Scale (PANSS) and Brief Neurocognitive Assessment (BNA) were administered. The correlations between the two ratings for the SWNS total and each item scores were high (r(s)=0.94 and r(s)=0.60-0.84, respectively); however, for 16 (80%) of 20 items, 5 or more patients (i.e., >= 10%) demonstrated a > 1 point score difference. There was no significant correlation between the SWNS total score difference and any clinical characteristics including age, education duration, illness duration, antipsychotic dose, psychopathology, and cognition. In contrast, the number of items with a > 1 point score difference was significantly correlated with disorganized symptoms and overall severity (r(s) = 0.29 for both), as well as working memory and global cognition (r(s) = -0.41 and r(s) = -0.40, respectively). These findings suggest that PROs should be interpreted with caution in patients with schizophrenia with prominent disorganization and cognitive impairment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.