[Mortality among the dye industry workers. II. An analysis of malignant neoplasm mortality].
[Mortality among the dye industry workers. II. An analysis of malignant neoplasm mortality].
复制标题
[染料行业工人的死亡率。
作者：
K. Sitarek;W. Szymczak;B. Barański
在一家生产不同种类染料（包括联苯胺）的工厂中，对工人的死亡率进行了研究。该队列包括8，523名男性和2，006名女性，他们的生命状态记录于1945年1月1日至1991年12月31日之间。从1945年1月1日到1974年12月31日，他们在这家工厂工作了至少3个月。队列分为4个亚队列：I.仅接触联苯胺的人：II.接触联苯胺和其他职业危害的人员; III.那些直接参与染料生产，但不暴露于联苯胺，和IV。那些不直接参与染料生产的人，主要是行政人员。死亡风险是根据人年法确定的标准化死亡率比（SMR）估计的。以波兰的一般人口作为参照组。将队列和每个子队列中观察到的死亡人数与预期死亡人数进行比较。这一比较是根据年龄、性别和日历时间调整后的国家比率进行的。在男性亚队列I中观察到膀胱癌导致的死亡率显著过高（SMR = 14.69），二（SMR = 16.34）和III（SMR = 3.17）;由于男性亚队列II中的胰腺恶性肿瘤（SMR = 3.26）;由于男性子队列III中的睾丸恶性肿瘤（SMR = 3.17）;由于男性子队列II中的胰腺恶性肿瘤（SMR = 3.26）;由于男性子队列III中的睾丸恶性肿瘤（SMR = 3.23）。在女性亚队列IV中发现了肝脏和肝内胆管恶性肿瘤导致的显著过度死亡（SMR = 2.36）。
A mortality study was carried out among workers employed in a plant producing different kinds of dyes, including benzidine. The cohort comprised 8,523 males and 2,006 females whose vital status was recorded between Jan 1, 1945 and Dec. 31, 1991. They had worked in this plant for, at least, 3 months between Jan. 1, 1945 and Dec 31, 1974. The cohort was divided into 4 subcohorts: I. those exposed only to benzidine: II. those exposed to benzidine and other occupational hazards; III. those involved directly in the dye production but not exposed to benzidine, and IV. those not involved directly in the dye production-mainly administrative staff. Death risk was estimated on the basis of standardized mortality ratio (SMR) determined by means of the person-years method. The general population of Poland was taken as a reference group. The observed number of deaths in the cohort and each subcohort was compared with expected deaths. The comparison was based on national rates by adjustment for age, gender and calendar time. Significant excessive mortality due to cancer of urinary bladder was observed in the male subcohort I (SMR = 14.69), II (SMR = 16.34) and III (SMR = 3.17); due to malignant neoplasm of pancreas in the male subcohort II (SMR = 3.26); due to malignant neoplasm of testis in the male subcohort III (SMR = 3.17); due to malignant neoplasm of pancreas in the male subcohort II (SMR = 3.26); due to malignant neoplasm of testis in the male subcohort III (SMR = 3.23). Significant excessive mortality due to malignant neoplasm of liver and intrahepatic bile ducts was found in the female subcohort IV (SMR = = 2.36).