High-level sensitivity of quantitative pp65 cytomegalovirus (CMV) antigenemia assay for diagnosis of CMV disease in AIDS patients and follow-up
High-level sensitivity of quantitative pp65 cytomegalovirus (CMV) antigenemia assay for diagnosis of CMV disease in AIDS patients and follow-up
复制标题
定量 pp65 巨细胞病毒 (CMV) 抗原血症检测用于诊断 AIDS 患者 CMV 疾病和随访的高灵敏度
DOI：
10.1128/jcm.34.2.457-459.1996
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发表时间：
1996
影响因子：
9.4
通讯作者：
G. Höffken
中科院分区：
文献类型：
--
作者：
B. Bek;M. Boeckh;J. Lepenies;B. Bieniek;K. Arastéh;W. Heise;K. Deppermann;Gudrun Bornhoft;M. Stöffler;I. Schuller;G. Höffken
对174例人类免疫缺陷病毒阳性患者进行了巨细胞病毒(CMV)抗原血症检测。96.7%的巨细胞病毒病患者、76.9%的疾病复发患者和11.4%的CD_4水平为100个/微升的无症状患者可检出抗原血症。在CD4水平为每微升250至500个细胞的患者中未检测到抗原血症。只有当每张玻片上有5个以上阳性细胞时，CMV病的特异度和阳性预测值才会增加。然而，CMV病也可能发生在低级别抗原血症的患者中。
Cytomegalovirus (CMV) antigenemia was evaluated in 174 patients positive for human immunodeficiency virus. Antigenemia could be detected in 96.7% of patients with CMV disease, 76.9% of patients suffering from a relapse of the disease, and 11.4% of asymptomatic patients with CD4 levels of < 100 cells per microliter. No antigenemia was detected in patients with CD4 levels of 250 to 500 cells per microliter. Specificity and the positive predictive value for CMV disease were increased only if more than 5 positive cells per slide were considered. However, CMV disease may also occur in patients with low-grade antigenemia.