Breast-feeding and neuroblastoma, USA and Canada
Breast-feeding and neuroblastoma, USA and Canada
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DOI：
10.1023/a:1015746701922
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发表时间：
2002-06-01
影响因子：
2.3
通讯作者：
Stram, DO
中科院分区：
文献类型：
--
作者：
Daniels, JL;Olshan, AF;Stram, DO
目的：研究人员提出母乳喂养与儿童癌症风险呈负相关。我们在美国和加拿大的一项大型病例对照研究中调查了母乳喂养和神经母细胞瘤之间的关系。方法：通过儿童癌症组和儿童肿瘤组确定的393名6个月及以上患有神经母细胞瘤的儿童和376名年龄匹配的对照组，通过电话访谈病例对照研究的随机数字拨号确定，比较了母亲母乳喂养的报告。结果：神经母细胞瘤患儿接受母乳喂养的可能性低于对照组患儿(优势比(OR) = 0.6；95%置信区间(CI) = 0.5-0.9)。母乳喂养与神经母细胞瘤的相关性随着母乳喂养时间的延长而增加（0-3个月OR = 0.7, CI = 0.4-1.0； 13个月以上OR = 0.5, CI = 0.3-0.9）。结论：母乳喂养与神经母细胞瘤呈负相关，应鼓励健康母亲母乳喂养。有必要对这种关联的可能机制进行进一步的研究。
Objective: Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case-control study in the United States and Canada.Methods: Maternal reports of breast-feeding were compared among 393 children six months or older who had neuroblastoma and were identified through the Children's Cancer Group and the Pediatric Oncology Group and 376 age-matched controls identified by random-digit telephone dialing in a telephone interview case-control study.Results: Children with neuroblastoma were less likely to have breast-fed than control children (odds ratio (OR) = 0.6; 95% confidence interval (CI) = 0.5-0.9). The association between breast-feeding and neuroblastoma increased with breast-feeding duration (0-3 months OR = 0.7, CI = 0.4-1.0; 13+ months OR = 0.5, CI = 0.3-0.9).Conclusion: Breast-feeding was inversely associated with neuroblastoma and should be encouraged among healthy mothers. Additional research on possible mechanisms of this association may be warranted.