Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group
Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group
复制标题
DOI：
10.1016/j.ica.2019.119066
复制
发表时间：
2019-11
影响因子：
2.8
通讯作者：
S. Meksawangwong;B. Gohil;Wikorn Punyain;R. Pal;F. Kielar
中科院分区：
文献类型：
--
作者：
S. Meksawangwong;B. Gohil;Wikorn Punyain;R. Pal;F. Kielar
合成、表征和研究了一种新型的含单一季铵盐基的三环金属Ir络合物(1)，作为一种潜在的细胞成像探针。该配合物是本课题组最近发表的新一代氨基烷基铱配合物。该络合物具有优异的光物理性质。该络合物在溶液中在黑暗中稳定，但表现出快速的光催化转化。对这一行为的研究表明，这些转化涉及形成亲电物种，该物种可以被合适的亲核试剂捕获，从而导致新产物的形成。该复合体也被作为潜在的细胞染色进行了研究。它的细胞毒性低于其氨基前身，并显示其前体的溶酶体定位。
A novel tris-cyclometalated iridium complex (1) containing a single quarternary ammonium moiety has been synthesized, characterized, and investigated as a potential cellular imaging probe. The complex is the next generation of the aminoalkyl iridium complexes recently published by our group. The complex possesses outstanding photophysical properties. The complex is stable in solution in dark but exhibits rapid photocatalyzed transformations. Investigations of this behavior have shown that these transformations involve the formation of an electrophilic species, which can be captured by a suitable nucleophile, leading to the formation of new product. The complex has also been investigated as a potential cellular stain. It is less cytotoxic than its aminoalkyl predecessor and shows lysosomal localization as its precursor.