Effect of protective ventilation on postoperative pulmonary complications in patients undergoing general anaesthesia: a meta-analysis of randomised controlled trials
Effect of protective ventilation on postoperative pulmonary complications in patients undergoing general anaesthesia: a meta-analysis of randomised controlled trials
复制标题
保护性通气对全身麻醉患者术后肺部并发症的影响：随机对照试验的荟萃分析
DOI：
10.1136/bmjopen-2014-005208
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发表时间：
2014-01-01
期刊：
影响因子：
2.9
通讯作者：
Deng, Xiaoming
中科院分区：
文献类型：
--
作者：
Tao, Tianzhu;Bo, Lulong;Deng, Xiaoming
目的：确定手术麻醉患者术中保护性通气策略是否有益。方法：检索截至2014年2月的MEDLINE、EMBASE和Cochrane中央对照试验注册库（Central）。符合条件的研究评估了在机械通气开始时无肺损伤的麻醉患者的保护性通气与常规通气的比较。主要观察指标是术后肺部并发症的发生率。纳入的研究必须报告以下至少一个终点：肺不张或急性肺损伤或肺部感染的发生率。结果：纳入4项研究（594例患者）。采用随机效应模型的荟萃分析显示肺不张发生率显著降低(OR=0.36; 95% CI 0.22 ~ 0.60; p
Objective: To determine whether anaesthetised patients undergoing surgery could benefit from intraoperative protective ventilation strategies.Methods: MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to February 2014. Eligible studies evaluated protective ventilation versus conventional ventilation in anaesthetised patients without lung injury at the onset of mechanical ventilation. The primary outcome was the incidence of postoperative pulmonary complications. Included studies must report at least one of the following end points: the incidence of atelectasis or acute lung injury or pulmonary infections.Results: Four studies (594 patients) were included. Meta-analysis using a random effects model showed a significant decrease in the incidence of atelectasis (OR=0.36; 95% CI 0.22 to 0.60; p