The effect of static exercise on renal sympathetic nerve activity in conscious cats.
The effect of static exercise on renal sympathetic nerve activity in conscious cats.
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静态运动对清醒猫肾交感神经活动的影响。
DOI：
10.1113/jphysiol.1991.sp018480
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Wilson,LB
中科院分区：
文献类型：
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作者：
Matsukawa,K;Mitchell,JH;Wall,PT;Wilson,LB
1. 在有意识的猫进行自愿静态（等长）运动时，同时测量肾脏交感神经活动（RNA）、心率（HR）、动脉血压（AP）和力发展。这些猫被公开训练用一只前肢按压一根杆。当施加在杆上的力超过预定值（阈值）时，蜂鸣器发出声音用于音频反馈。如果猫在26 - 55秒内继续产生适当的力量，则给予食物作为奖励。2. 7只猫共进行了89项运动试验。施加在杆上的峰值力为468 +/‐28 g（平均值+/‐S.E.M.）。在静态运动期间，RNA、HR和AP分别较对照组显著增加102 +/‐14%、23 +/‐2次/min和11 +/‐1 mmHg。3. RNA的增加既有初始成分，也有后期成分。初始分量发生在力发展开始之前或之前，持续10 s，而后期分量在静态运动开始后14 s逐渐增加，并持续到运动结束。4. HR在静态运动开始时也增加，其时间过程与RNA相似。然后，HR恢复到控制值，并在剩余的运动期间保持在该水平。AP的增加比RNA的初始增加延迟了10 s，然后在整个运动期间继续上升。5. 在休息时发出蜂鸣器的声音，以确定预期或条件对反应的任何影响。RNA和AP略有升高，但HR没有变化。RNA和AP的增加远远小于静态运动时的增加。因此，静态运动期间RNA、HR和AP的增加似乎与运动本身有关，而不是由于预期和/或条件作用。6. 当大量注射去甲肾上腺素升高AP时，休息时RNA几乎被消除，静止运动时RNA的增加明显被抑制。因此，动脉压力反射在休息和静态运动时都会显著影响RNA。7. 这项研究表明，在有意识的猫开始静态运动时，RNA和HR的最初增加是由来自高级脑中心的下降输入引起的，而不是由肌肉受体或动脉压力感受器的传入反馈信号引起的。（摘要删节为400字）
1. Renal sympathetic nerve activity (RNA), heart rate (HR), arterial blood pressure (AP), and force development were measured simultaneously during voluntary static (isometric) exercise performed by conscious cats. The cats were operantly trained to press a bar with one forelimb. When the force applied to the bar exceeded a predetermined value (threshold), a sound was emitted by a buzzer for audio‐feedback. If the cat continued to produce the appropriate force for a period of 26‐55 s, food was given as a reward. 2. A total of eighty‐nine exercise trials were performed by seven cats. The peak force applied to the bar was 468 +/‐ 28 g (mean +/‐ S.E.M.). RNA, HR, and AP increased significantly from the control value during static exercise by 102 +/‐ 14%, 23 +/‐ 2 beats/min, and 11 +/‐ 1 mmHg, respectively. 3. The increase in RNA had both an initial and a late component. The initial component occurred at or immediately before the onset of force development and lasted for 10 s, while the late component gradually increased 14 s after the onset of static exercise and was sustained until the exercise was terminated. 4. HR also increased at the beginning of static exercise with a similar time course as RNA. Then, HR returned to the control value and remained at that level during the remainder of exercise. The increase in AP was delayed by 10 s from the initial increase in RNA and then continued to rise throughout the period of exercise. 5. The sound of the buzzer was emitted during rest to determine any influence of anticipation or conditioning on the response. RNA and AP increased slightly, but HR did not change. The increases in RNA and AP were much smaller than the increases obtained during static exercise. Thus, the increases in RNA, HR and AP during static exercise appeared to be associated with the exercise itself and not due to anticipation and/or conditioning. 6. When AP was elevated by a bolus injection of noradrenaline, RNA during rest was almost abolished and the increase of RNA during static exercise was markedly inhibited. Thus the arterial baroreflex significantly influences RNA both during rest and during static exercise. 7. This study suggests that the initial increases in RNA and HR at the beginning of static exercise in conscious cats are caused by descending input from higher brain centres and not by afferent feedback signals from muscle receptors or by arterial baroreceptors.(ABSTRACT TRUNCATED AT 400 WORDS)