Immunopathogenesis of Pneumocystis carinii pneumonia
Immunopathogenesis of Pneumocystis carinii pneumonia
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DOI：
10.1017/s1462399405010203
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发表时间：
2005-11-14
影响因子：
6.2
通讯作者：
Wright, Terry W.
中科院分区：
文献类型：
--
作者：
Gigliotti, Francis;Wright, Terry W.
卡氏肺孢子虫肺炎（PCP）是一种危及生命的感染，发生在免疫功能低下的个体，特别是晚期人类免疫缺陷病毒（HIV）感染者。有趣的是，发病率和死亡率与免疫抑制的根本原因有关，例如艾滋病患者的情况比肿瘤患者好。此外，PCP的预后与炎症标志物相关，而不是与微生物数量相关。现在有越来越多的证据表明，PCP期间发生的肺损伤是宿主对卡氏肺孢子虫的炎症反应的类型和程度的结果，而不是生物体直接损伤的结果。本文将讨论的实验和临床数据表明，宿主介导的炎症反应感染卡氏肺孢子虫决定了PCP的最终结果。更好地了解PCP的病理生理学应导致开发用于治疗PCP的改进疗法。
Pneumocystis carinii pneumonia (PCP) is a life-threatening infection that occurs in immunocompromised individuals, particularly those with advanced human immunodeficiency virus (HIV) infection. Interestingly, morbidity and mortality is related to the underlying cause of immunosuppression, with AIDS patients faring better than oncology patients for example. In addition, the prognosis of PCP has been correlated with markers of inflammation rather than with organism numbers. There is now increasing evidence that lung damage occurring during PCP is a result of the type and extent of the host inflammatory response to P. carinii rather than a result of direct damage by the organism. This review will discuss the experimental and clinical data demonstrating how the host-mediated inflammatory response to infection with P. carinii determines the ultimate outcome of PCP. A better understanding of the pathophysiology of PCP should lead to the development of improved therapies for the treatment of PCP.