An fMRI study of multimodal semantic and phonological processing in reading disabled adolescents
An fMRI study of multimodal semantic and phonological processing in reading disabled adolescents
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DOI：
10.1007/s11881-009-0029-6
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发表时间：
2010-06-01
影响因子：
2.3
通讯作者：
Pugh, Kenneth R.
中科院分区：
文献类型：
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作者：
Landi, Nicole;Mencl, W. Einar;Pugh, Kenneth R.
使用功能磁共振成像，我们调查了多模态（视觉和听觉）语义和单峰（仅视觉）语音加工的阅读障碍（RD）青少年和非受损（NI）控制参与者。我们发现，在所有处理任务中，无论任务类型（语义与语音）或方式（听觉与视觉方式），RD相对于NI在一些左半球阅读相关区域的激活减少。此外，激活差异，在这些地区，其中包括额下回，上级颞回，枕颞区，在很大程度上独立于在扫描性能在我们的听觉语义任务。也就是说，虽然RD参与者和NI参与者在视觉呈现条件下的表现不同，但在听觉条件下没有显着差异，但在这些区域中观察到类似的激活减少模式。这些发现表明RD的神经生物学标志物与任务、方式或表现无关。这些研究结果的背景下，目前的神经生物学模型的RD进行了讨论。
Using functional magnetic resonance imaging, we investigated multimodal (visual and auditory) semantic and unimodal (visual only) phonological processing in reading disabled (RD) adolescents and non-impaired (NI) control participants. We found reduced activation for RD relative to NI in a number of left-hemisphere reading-related areas across all processing tasks regardless of task type (semantic vs. phonological) or modality (auditory vs. visual modality). Moreover, activation differences in these regions, which included the inferior frontal gyrus, the superior temporal gyrus, and the occipitotemporal region, were largely independent of in-scanner performance in our auditory semantic task. That is, although RD participants and NI participants differed in performance in visually presented conditions, they did not differ significantly in the auditory condition, yet similar patterns of reduced activation were observed in these regions across conditions. These findings indicate a neurobiological marker in RD that is independent of task, modality, or performance. These findings are discussed in the context of current neurobiological models of RD.