POTENTIAL EFFICACY OF CHLORHEXIDINE AGAINST MUTANS STREPTOCOCCI AND HUMAN DENTAL-CARIES
POTENTIAL EFFICACY OF CHLORHEXIDINE AGAINST MUTANS STREPTOCOCCI AND HUMAN DENTAL-CARIES
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DOI：
10.1177/00220345940730031401
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发表时间：
1994-03-01
影响因子：
7.6
通讯作者：
EMILSON, CG
中科院分区：
文献类型：
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作者：
EMILSON, CG
化学治疗剂被认为具有预防龋齿的潜力。几种物质已被评估为可能的候选物，但除氟化物外，没有一种抗菌剂像双胍氯己定一样受到实验关注。这种物质是迄今为止最有效和最有据可查的制剂。为了有效对抗龋齿，必须在足够但有限的时间段内向具有已形成的致龋菌斑的部位给予治疗剂量的抗微生物剂。在使用这一原则的研究中，目的是消除或强烈抑制变形链球菌的种群。在测试的各种抗微生物剂和方法中，氯己定清漆实现了变形链球菌最持久的减少，其次是凝胶和漱口水。最好的临床效果，导致相当大的龋齿减少时，已获得的人高度定植与变形链球菌已与凝胶治疗，当抗菌剂的结果。已通过微生物检查对措施进行了验证。
Chemotherapeutic agents have been considered as having potential for the prevention of dental caries. Several substances have been evaluated as possible candidates, but no antimicrobial agent, with the exception of fluoride, has received as much experimental attention as the bisbiguanide chlorhexidine. This substance represents, so far, the most effective and best-documented agent. To be effective against caries, therapeutic dosages of the antimicrobial agent have to be given for a sufficient but finite time period to sites with established cariogenic plaque. In studies where this principle has been used, the aim has been to eliminate or strongly suppress the population of mutans streptococci. Of various antimicrobial agents and methods tested, the most persistent reduction of mutans streptococci has been achieved by chlorhexidine varnishes, followed by gels and mouthwashes. The best clinical effect resulting in a considerable caries reduction has been obtained when persons highly colonized with mutans streptococci have been treated with gels and when the results of the antimicrobial. measures have been verified by microbiological examination.