Modes of phagocytosis of Gram-positive and Gram-negative bacteria by Spodoptera littoralis granular haemocytes
Modes of phagocytosis of Gram-positive and Gram-negative bacteria by Spodoptera littoralis granular haemocytes
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DOI：
10.1016/j.jinsphys.2004.10.014
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发表时间：
2005-01-01
影响因子：
2.2
通讯作者：
Brehélin, M
中科院分区：
文献类型：
--
作者：
Costa, SCP;Ribeiro, C;Brehélin, M
红细胞是昆虫细胞免疫反应的主要免疫活性细胞。在这里，我们表明，无论在体内还是在体外，颗粒状血细胞都是主要的吞噬细胞血细胞。哺乳动物巨噬细胞的“触发”和“拉链”吞噬模式是活跃的，在体内，在S. littoralis颗粒状血细胞中，连同巨噬细胞作用。脂多糖和脂壁酸抑制革兰氏阳性（干燥棒状杆菌）和革兰氏阴性（大肠杆菌）细菌在颗粒血细胞上的结合。此外，不同的配体可以抑制大肠杆菌的结合。大多数这些抑制剂在哺乳动物巨噬细胞中被称为清食剂受体的配体，我们假设存在于滨海棘豆颗粒血细胞中的受体之一可能是一种类似清食剂的受体。(C) 2004 Elsevier Ltd.版权所有。
Haemocytes are the main immunocompetent cells in insect cellular immune reactions. Here, we show that in Spodoptera littoralis, granular haemocytes are the primary phagocyte haemocytes, both in vivo and in vitro. The "trigger" and "zipper" modes of engulfment known in mammal macrophages are active, in vivo, in S. littoralis granular haemocytes, together with macropinocytosis. Lipopolysaccharide as well as lipoteichoic acid inhibit the binding of both Gram-positive (Corynebacterium xerosis) and Gramnegative (Escherichia coli) bacteria on granular haemocytes. In addition, different ligands can inhibit the binding of E coli. Most of these inhibitors are known as ligands of scavenger receptors in mammal macrophages and we hypothesise that one of the receptors present on S. littoralis granular haemocytes could be a scavenger-like receptor. (C) 2004 Elsevier Ltd. All rights reserved.