Cellular kinetics associated with the development of acquired cellular resistance.
Cellular kinetics associated with the development of acquired cellular resistance.
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DOI：
10.1084/jem.130.2.299
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发表时间：
1969-08-01
期刊：
影响因子：
--
通讯作者：
North RJ
中科院分区：
文献类型：
--
作者：
North RJ
感染BCG或单核细胞增生李斯特菌的小鼠显示出相同类型的细胞反应模式。在这两种感染中，脾淋巴样细胞强烈增殖，分化的巨噬细胞同时增殖，随后产生代谢潜力增加的巨噬细胞。这些事件之间的时间关系和主机电阻的发病表明，淋巴细胞增殖和巨噬细胞增殖的反应，导致细胞抵抗兼性细胞内寄生虫是必不可少的事件。
Mice infected with either BCG or Listeria monocytogenes display the same type of cellular response pattern. In both infections there is an intense proliferation of splenic lymphoid cells, a coincident proliferation of differentiated macrophages, and a subsequent production of macrophages with increased metabolic potential. The temporal relations between these events and the onset of host resistance indicate that lymphoid cell proliferation and macrophage proliferation are essential events in the response which leads to cellular resistance against facultative intracellular parasites.