Cellular Dysfunction in Sepsis
Cellular Dysfunction in Sepsis
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DOI：
10.1016/j.ccm.2008.06.003
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发表时间：
2008-12-01
影响因子：
5.7
通讯作者：
Singer, Mervyn
中科院分区：
文献类型：
--
作者：
Singer, Mervyn
细胞功能障碍是败血症和其他全身性炎症性疾病的常见后遗症。能量产生受损（与线粒体抑制、损伤和蛋白质周转减少有关）似乎是器官功能障碍发展的核心机制。能量可用性的减少似乎引发了代谢关闭，损害了细胞的正常功能。这很可能代表了一种类似于冬眠的适应机制，可以防止大规模的细胞死亡，从而使幸存者最终能够恢复。
Cellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availability appears to trigger a metabolic shutdown that impairs normal functioning of the cell. This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors.