Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells.
Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells.
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Qa 基因表达：活化 T 细胞中 Qa-2 分子的生物合成和分泌。
DOI：
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发表时间：
1986
影响因子：
11.1
通讯作者：
A. Lattimore
中科院分区：
文献类型：
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作者：
M. Soloski;J. Vernachio;G. Einhorn;A. Lattimore
组织特异性I类分子Qa-2的生物合成和表达已经在静息和活化的T细胞群体中进行了研究。T淋巴细胞的多克隆活化诱导Qa-2分子的生物合成增加3至4倍，但细胞表面水平没有增加。在活化的淋巴细胞中的Qa-2分子的生物合成途径的分析揭示，大约等于70%的新合成的Qa-2分子作为可溶性分子分泌。在静息细胞群体中，Qa-2保持完全细胞相关。该过程对于Qa-2分子是独特的，因为其他I类分子（例如，H-2Kb和H-2Db）保持细胞结合。分泌的Qa-2分子被认为是一个新的Qa基因或选择性剪接的mRNA的产物的可能性。这些结果表明，Qa-2分子可能不仅作为一个细胞表面识别结构，但也可以作为一个激活的淋巴细胞群合成的可溶性因子的作用。
The biosynthesis and expression of the tissue-specific class I molecule Qa-2 have been studied in resting and activated T-cell populations. Polyclonal activation of T lymphocytes induces a 3- to 4-fold increase in the biosynthesis of Qa-2 molecules but no increase in cell-surface levels. Analysis of the biosynthetic pathway of the Qa-2 molecule in activated lymphocytes reveals that approximately equal to 70% of the newly synthesized Qa-2 molecules are secreted as soluble molecules. In resting-cell populations, Qa-2 remains entirely cell-associated. This process is unique to the Qa-2 molecule, since other class I molecules (e.g., H-2Kb and H-2Db) synthesized by activated cells remain cell-associated. The possibility that the secreted Qa-2 molecule is the product of a new Qa gene or an alternatively spliced mRNA is considered. These results indicate that the Qa-2 molecules may not just function as a cell-surface recognition structure but also may serve a role as a soluble factor synthesized by activated lymphoid cell populations.