High-betweenness proteins in the yeast protein interaction network.
High-betweenness proteins in the yeast protein interaction network.
复制标题
酵母蛋白相互作用网络中的高比分蛋白。
DOI：
10.1155/jbb.2005.96
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发表时间：
2005-06-30
影响因子：
--
通讯作者：
Huang, S
中科院分区：
文献类型：
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作者：
Joy, MP;Brock, A;Ingber, DE;Huang, S
在生物分子网络中发现的结构特征，在简单算法产生的随机网络中是不存在的，可以为细胞调节网络的功能和进化提供见解。本文分析了酵母蛋白相互作用网络中网络节点的“中间度”，这是一种图理论中心性度量。在酵母蛋白质组中发现了大量具有高间接性但低连接度的蛋白质。这一发现不能用解释蛋白质相互作用网络无标度特性的算法来解释，其中低连通性的蛋白质也具有低之间性。这些数据表明该网络存在一些模块化组织，而高间隔、低连接的蛋白质可能是这些模块之间的重要链接。我们发现，高中间度的蛋白质更可能是必需的，蛋白质的进化年龄与中间度正相关。通过比较产生无标度网络的不同基因组进化模型，我们表明，通过突变重新连接相互作用是产生此类蛋白质的重要因素。讨论了这些观察结果的进化和功能意义。
Structural features found in biomolecular networks that are absent in random networks produced by simple algorithms can provide insight into the function and evolution of cell regulatory networks. Here we analyze “betweenness” of network nodes, a graph theoretical centrality measure, in the yeast protein interaction network. Proteins that have high betweenness, but low connectivity (degree), were found to be abundant in the yeast proteome. This finding is not explained by algorithms proposed to explain the scale-free property of protein interaction networks, where low-connectivity proteins also have low betweenness. These data suggest the existence of some modular organization of the network, and that the high-betweenness, low-connectivity proteins may act as important links between these modules. We found that proteins with high betweenness are more likely to be essential and that evolutionary age of proteins is positively correlated with betweenness. By comparing different models of genome evolution that generate scale-free networks, we show that rewiring of interactions via mutation is an important factor in the production of such proteins. The evolutionary and functional significance of these observations are discussed.