Improving African American women's engagement in clinical research: A systematic review of barriers to participation in clinical trials.
Improving African American women's engagement in clinical research: A systematic review of barriers to participation in clinical trials.
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DOI：
10.1016/j.jnma.2022.02.004
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发表时间：
2022-06
影响因子：
3.3
通讯作者：
Price, Olga Acosta
中科院分区：
文献类型：
--
作者：
Le, Daisy;Ozbeki, Hanna;Salazar, Stefanie;Berl, Madison;Turner, Monique Mitchell;Price, Olga Acosta
尽管多方努力，非裔美国妇女在临床研究中的代表性仍然不足，而在疾病中的代表性过高，产生的研究结果对这一特定人群的普遍性有限。我们对种族/少数民族患者参与临床试验的障碍的理解已经发生了变化，但很少有研究探讨非洲裔美国妇女决定不参加临床试验的原因。主要目的是进行系统性综述，以确定非洲裔美国妇女报告的参与临床研究的障碍，以帮助解释低水平的入学率。我们还提出了研究界可以实施的策略，以减轻这些障碍的影响。通过MEDLINE、SCOPUS、Web of Science和Google Scholar进行检索。根据一组合格标准，共选择了18篇同行评议的期刊文章，并进行了分析，以呈现类别和主题。在旨在检查其独特观点的研究中，非裔美国妇女提到的不参加临床研究的原因分为三大类：1）与医学和研究界的关系薄弱，2）参与成本高，3）个人和“遥不可及”的情况。与参与者与医生/研究人员的关系有关的原因最突出。有针对性的和全面的了解影响非洲裔美国妇女决定参加临床研究的障碍，为未来的研究提供特定人群的招募和研究策略。评估参与临床试验研究障碍的其他研究，不仅按种族/民族而且按性别报告分类数据，对于改善广泛的预防和治疗工作的风险/获益概况至关重要。这种对少数群体内各亚群之间差异的更好理解，对于支持文化敏感信息，以加强少数群体参与临床试验研究具有重要意义。
Despite multiple efforts, African American women continue to be inadequately represented in clinical research while being overrepresented in disease, producing research results with limited generalizability to this specific population. Our understanding of the barriers to participation in clinical trials among racial/ethnic minority patients in general has evolved, but few studies have examined the reasoning behind African American women’s decision to not participate in clinical trials. The primary aim was to conduct a systematic review to identify the barriers reported by African American women regarding participation in clinical research to help explain the low levels of enrollment. We also suggest strategies that can be implemented by the research community to lessen the effect of those barriers. Searches were conducted through MEDLINE, SCOPUS, Web of Science, and Google Scholar. Following a set of eligibility criteria, a total of 18 peer-reviewed journal articles were selected and analyzed to render categories and themes. Across studies aimed at examining their unique perspective, the reasons mentioned by African American women for not participating in clinical research were grouped in three broad categories: 1) weak relationship with the medical and research community, 2) high cost to participation, and 3) personal and “out-of-reach” circumstances. Reasons pertaining to participants’ relationship with physicians/researchers were most salient. A targeted and comprehensive understanding of the barriers impacting African American women’s decision to participate in clinical research informs population-specific recruitment and research strategies for future studies. Additional studies assessing barriers to clinical trial research participation that intentionally report on disaggregated data by not only race/ethnicity but also sex are essential to improving the risk/benefit profile for a wide range of prevention and treatment efforts. This improved understanding of the differences between subgroups within minority populations has implications for bolstering culturally sensitive messages to enhance the engagement of minority communities in clinical trial research.
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DOI：
10.1016/0749-5978(91)90020-t
发表时间：
1991-12-01
影响因子：
4.6
作者：
AJZEN, I
通讯作者：
AJZEN, I
影响因子：
7.4
作者：
Geller, Stacie E.;Koch, Abigail R.;Carnes, Molly
通讯作者：
Carnes, Molly
影响因子：
7.2
作者：
Aaker, JL;Williams, P
通讯作者：
Williams, P
影响因子：
5.5
作者：
Voytek, Chelsea D.;Jones, Kevin T.;Metzger, David S.
通讯作者：
Metzger, David S.
影响因子：
1.2
作者：
Black, Iain;Baines, Paul;Mortimore, Roger
通讯作者：
Mortimore, Roger