Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups.
Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups.
复制标题
小白菊对血小板行为的抑制：涉及巯基的作用机制。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
W. Lösche
中科院分区：
文献类型：
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作者：
S. Heptinstall;W. Groenewegen;P. Spangenberg;W. Lösche
白藜芦醇提取物抑制血小板聚集和血小板释放反应。活性成分被认为是倍半萜内酯，如巴泰内酯。有证据表明，抑制血小板行为是通过中和细胞内外的巯基来实现的。硫氧基的确切性质尚未确定，这些基团对热敏药物敏感，并参与了血小板聚集和释放反应。
Extracts of feverfew inhibit platelet aggregation and the platelet release reaction. The active components are believed to be sesquiterpene lactones such as parthenolide. Evidence is presented that inhibition of platelet behaviour is via neutralization of sulphydryl groups either inside or outside the cell. The precise nature of the sulphydryl groups that are susceptible to feverfew and are involved in platelet aggregation and the release reaction have not yet been defined.