NEUTROPHIL RECRUITMENT BY TUMOR-NECROSIS-FACTOR FROM MAST-CELLS IN IMMUNE-COMPLEX PERITONITIS
NEUTROPHIL RECRUITMENT BY TUMOR-NECROSIS-FACTOR FROM MAST-CELLS IN IMMUNE-COMPLEX PERITONITIS
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DOI：
10.1126/science.1470922
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发表时间：
1992-12-18
期刊：
影响因子：
56.9
通讯作者：
JAKSCHIK, BA
中科院分区：
文献类型：
--
作者：
ZHANG, Y;RAMOS, BF;JAKSCHIK, BA
在全身免疫复合物诱导的腹腔炎症过程中，在正常小鼠腹腔渗出液中观察到两个肿瘤坏死因子（TNF）峰。在肥大细胞缺陷的小鼠中，第一个峰未被检测到，并且TNF和中性粒细胞流入的第二个峰显著减少。TNF抗体显着抑制中性粒细胞浸润正常，但在肥大细胞缺陷小鼠。后者的肥大细胞补充使TNF、中性粒细胞动员和TNF抗体的作用正常化。因此，在体内，肥大细胞产生TNF，增强中性粒细胞迁移。
During generalized immune complex-induced inflammation of the peritoneal cavity, two peaks of tumor necrosis factor (TNF) were observed in the peritoneal exudate of normal mice. In mast cell-deficient mice, the first peak was undetected, and the second peak of TNF and neutrophil influx were significantly reduced. Antibody to TNF significantly inhibited neutrophil infiltration in normal but not in mast cell-deficient mice. Mast cell repletion of the latter normalized TNF, neutrophil mobilization, and the effect of the antibody to TNF. Thus, in vivo, mast cells produce the TNF that augments neutrophil emigration.