Supplementary motor area exerts proactive and reactive control of arm movements.
Supplementary motor area exerts proactive and reactive control of arm movements.
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DOI：
10.1523/jneurosci.2669-10.2010
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发表时间：
2010-11-03
期刊：
影响因子：
--
通讯作者：
Stuphorn V
中科院分区：
文献类型：
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作者：
Chen X;Scangos KW;Stuphorn V
适应性行为需要灵活控制行为的能力。这既可以主动地预测任务需求，也可以被动地响应突然的变化。在这里，我们报告的神经元活动的补充运动区（SMA），这是相关的两种形式的行为控制。在猕猴的停止信号任务中记录了单个和多个单位的活动和颅内局部场电位（LFP），这两种行为控制都是主动和反应性的。在高（60-150 Hz）和低（25-40 Hz）频段的LFP功率与手臂运动反应时间显著相关，在目标开始之前开始。多单位和单单位活动也显示出显着的回归与反应时间。此外，LFP、多单位活动和单单位活动根据试验历史改变了其活动水平，反映了行为水平的调整。总之，这些发现表明，SMA中的神经元活动通过调节运动准备水平来主动控制手臂运动。在试验中，当猴子成功地取消手臂运动以响应不可预见的停止信号时，LFP功率（特别是在低（10-50 Hz）频率范围内）增加得足够早，从而与这些试验中手臂运动的抑制有因果关系。这表明SMA中的神经元活动也参与对突然任务变化的反应抑制。因此，我们的研究结果表明，SMA在主动控制运动准备和反应性抑制不必要的运动中发挥作用。
Adaptive behavior requires the ability to flexibly control actions. This can occur either proactively to anticipate task requirements, or reactively in response to sudden changes. Here we report neuronal activity in the supplementary motor area (SMA) that is correlated with both forms of behavioral control. Single and multi-unit activity and intracranial local field potentials (LFP) were recorded in macaque monkeys during a stop signal task, which elicits both proactive and reactive behavioral control. The LFP power in high (60-150 Hz) and low (25-40 Hz) frequency bands was significantly correlated with arm movement reaction time, starting before target onset. Multi- and single unit activity also showed a significant regression with reaction time. In addition, LFPs, multi- and single unit activity changed their activity level depending on the trial history, mirroring adjustments on the behavioral level. Together, these findings indicate that neuronal activity in the SMA exerts proactive control of arm movements by adjusting the level of motor readiness. On trials when the monkeys successfully canceled arm movements in response to an unforeseen stop signal, the LFP power particularly in a low (10-50 Hz) frequency range increased early enough to be causally related to the inhibition of the arm movement on those trials. This indicated that neuronal activity in the SMA is also involved in response inhibition in reaction to sudden task changes. Our findings indicate therefore that SMA plays a role in the proactive control of motor readiness and the reactive inhibition of unwanted movements.