Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk
Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk
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DOI：
10.1002/pros.10115
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发表时间：
2002-09-01
期刊：
影响因子：
2.8
通讯作者：
Comstock, GW
中科院分区：
文献类型：
--
作者：
Platz, EA;Helzlsouer, KJ;Comstock, GW
背景。镉是一种公认的人类肺癌致癌物，也与前列腺癌呈正相关，主要发生在职业暴露的男性中。饮食和补充锌摄入量与前列腺癌之间的关联 11,15 在流行病学研究中并不一致。我们在一个队列中评估了诊断前脚趾甲镉和锌浓度与前列腺癌风险之间的关联，其中镉和锌的主要暴露途径是饮食。方法。分析中包括位于马里兰州华盛顿县的前瞻性 CLUE II 研究中的 115 名前列腺癌病例和 227 名年龄匹配的对照者。参与者在 1989 年提供了基线脚趾甲样本。炉原子吸收和火焰原子吸收分别用于测定脚趾甲中的镉和锌浓度。比值比 (OR) 和 95% 置信区间 (CI) 是根据条件逻辑回归模型估计的。 结果。前列腺癌病例（镉，45.9 ppb；锌，155.3 ppm）和对照组（镉，54.5 ppb；锌，164.0 ppm）之间脚趾甲镉和锌浓度中位数没有统计学显着差异。前列腺癌风险并不随着镉浓度的增加而增加（P 趋势 = 0.9），也不随着锌浓度的增加而降低（P 趋势 = 0.2）。对于这两种金属，与后五分之一相比，前四五分之一的 OR 均低于 1.0。结论。在一般人群样本中观察到的趾甲镉浓度较高的男性，患前列腺癌的风险并未增加。尽管没有证据表明存在线性剂量反应，但这些研究结果表明，中等和较高锌摄入量的男性患前列腺癌的风险可能略低。
BACKGROUND. Cadmium is a recognized human lung carcinogen that has also been positively associated with prostate cancer mainly in occupationally exposed men. The association between dietary and supplemental zinc intake and prostate cancer 11,15 not been consistent in epidemiologic studies. We evaluated the association between prediagnostic toenail cadmium and zinc concentrations and risk of prostate cancer in a cohort in which the primary route of exposure to cadmium and zinc is the diet.METHODS. Included in the analysis were 115 prostate cancer cases and 227 age-matched controls nested in the prospective CLUE II study located in Washington County, MD. Participants provided toenail samples at baseline in 1989. Furnace atomic absorption and flame atomic absorption were used to determine toenail cadmium and zinc concentrations, respectively. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from conditional logistic regression models.RESULTS. Median toenail cadmium and zinc concentrations did not statistically significantly differ between prostate cancer cases (cadmium, 45.9 ppb; zinc, 155.3 ppm) and controls (cadmium, 54.5 ppb; zinc, 164.0 ppm). Prostate cancer risk did not increase with increasing concentrations of cadmium (P trend = 0.9) and did not decrease with increasing concentrations of zinc (P trend = 0.2). For both metals, the ORs for the top four fifths were each below 1.0 when compared with the bottom fifth.CONCLUSION. Men who have high toenail cadmium concentrations in the range observed in this general population sample were not at an increased risk for prostate cancer. Although there was no evidence of a linear dose-response, these findings suggest that risk of prostate cancer may be slightly lower among men with moderate and higher zinc intake.