Cellular automaton simulation examining progenitor hierarchy structure effects on mammary ductal carcinoma in situ
Cellular automaton simulation examining progenitor hierarchy structure effects on mammary ductal carcinoma in situ
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DOI：
10.1016/j.jtbi.2007.01.011
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发表时间：
2007-06-07
影响因子：
2
通讯作者：
Heckendorn, Robert B.
中科院分区：
文献类型：
--
作者：
Bankhead, Armand, III;Magnuson, Nancy S.;Heckendorn, Robert B.
计算机模拟用于模拟导管原位癌，一种非侵入性乳腺癌。该模拟使用已知的组织学形态、细胞类型和随机细胞增殖来发展导管内的肿瘤生长。管道模拟是基于一个混合的元胞自动机设计，使用遗传规则来确定每个细胞的行为。遗传规则是一个可变的抽象，表明在人口的遗传异质性。我们的目标是研究最近发现的乳腺干细胞等级在遗传异质性、DCIS启动和侵袭性中的作用（如果有的话）。结果表明，更简单的祖先层次导致更大的遗传异质性和DCIS的发展显着更快。然而，更复杂的祖细胞层次结构能够维持癌细胞群体的快速繁殖更长的时间。爱思唯尔有限公司出版
A computer simulation is used to model ductal carcinoma in situ, a form of non-invasive breast cancer. The simulation uses known histological morphology, cell types, and stochastic cell proliferation to evolve tumorous growth within a duct. The ductal simulation is based on a hybrid cellular automaton design using genetic rules to determine each cell's behavior. The genetic rules are a mutable abstraction that demonstrate genetic heterogeneity in a population. Our goal was to examine the role (if any) that recently discovered mammary stem cell hierarchies play in genetic heterogeneity, DCIS initiation and aggressiveness. Results show that simpler progenitor hierarchies result in greater genetic heterogeneity and evolve DCIS significantly faster. However, the more complex progenitor hierarchy structure was able to sustain the rapid reproduction of a cancer cell population for longer periods of time. Published by Elsevier Ltd.