Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women
Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women
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DOI：
10.1002/dmrr.2898
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发表时间：
2017-09-01
影响因子：
8
通讯作者：
Sone, Hirohito
中科院分区：
文献类型：
--
作者：
Tajima, Ryoko;Yachi, Yoko;Sone, Hirohito
背景在东亚国家，体重过轻的人群普遍存在，关于饮食因素与妊娠期糖耐量异常之间的关系的信息很少。我们研究了碳水化合物的摄入量和适度异常的葡萄糖耐量之间的关联在日本孕妇。MethodsWe进行了一项前瞻性研究，对325日本孕妇没有诊断糖尿病怀孕前。膳食碳水化合物摄入量（占总能量摄入量的百分比）使用妊娠第8-15周期间的3天膳食记录进行评估。在妊娠24-28周期间，通过50 g葡萄糖激发试验（GCT）评估葡萄糖耐量。阳性GCT结果定义为1小时血浆浓度7.8 mmol/L。阳性GCT的优势比计算的顶部和中间三分位类别的碳水化合物摄入量使用底部类别作为reference.ResultsMean（标准差）的体重指数在第一次产前检查为19.7（1.9）kg/m2，和95名妇女体重不足。74名妇女的GCT结果呈阳性。在校正了年龄、产次、首次产前检查时的体重指数、糖尿病家族史、妊娠期体重增加率、能量摄入和膳食纤维摄入后，碳水化合物摄入与GCT阳性结果呈负相关（最高类别的比值比：0.46 [95% CI，0.23-0.93]）结论这些发现表明，高碳水化合物摄入量与中度糖耐量异常的高患病率人群呈负相关，体重不足的人。
BackgroundIn East Asian countries, which have a high prevalence of underweight individuals, there is little information about the association between dietary factors and abnormal glucose tolerance during pregnancy. We examined the association between carbohydrate intake and moderately abnormal glucose tolerance in Japanese pregnant women.MethodsWe conducted a prospective study on 325 Japanese pregnant women without a diagnosis of diabetes mellitus prior to pregnancy. Dietary carbohydrate intake (% of total energy intake) was assessed using a 3-day dietary record during weeks 8-15 of pregnancy. Glucose tolerance was assessed by the 50g glucose challenge test (GCT) during weeks 24-28 of pregnancy. A positive GCT result was defined by a 1-hour plasma concentration7.8mmol/L. Odds ratios of a positive GCT were calculated for the top and middle tertile categories of carbohydrate intake using the bottom category as reference.ResultsMean (standard deviation) body mass index at the first prenatal visit was 19.7 (1.9) kg/m(2), and 95 women were underweight. Seventy-four women had positive GCT results. Carbohydrate intake was negatively associated with a positive GCT result after adjusting for age, parity, body mass index at first prenatal visit, family history of diabetes mellitus, rate of gestational weight gain, energy intake, and dietary fiber intake (odds ratio for top category: 0.46 [95% CI, 0.23-0.93]).ConclusionsThese findings suggest that high carbohydrate intake was negatively associated with moderately abnormal glucose tolerance in a population with a high prevalence of underweight individuals.