Thiamin and pyridoxine requirements during intravenous hyperalimentation.
Thiamin and pyridoxine requirements during intravenous hyperalimentation.
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静脉营养过度期间硫胺素和吡哆醇的需求。
DOI：
10.1093/ajcn/32.2.332
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Yoji Takagi
中科院分区：
文献类型：
--
作者：
H. Kishi;S. Nishii;T. Ono;A. Yamaji;N. Kasahara;E. Hiraoka;Akira Okada;Takeo Itakura;Yoji Takagi
为了确定长期静脉高营养期间维生素B1和B6的合理剂量，研究人员采用了比以前更灵敏的技术来评估维生素B1和B6的状态。一种标准的维生素组合，A型，（通常是市售产品）一直使用至今，因为方便，不考虑长期服用的影响。这种组合不含生物素、叶酸和维生素E，其含量是维生素B1、B2、B6、B12和C的10到100倍。为了应对维生素过量的可能性，开发了两种新的维生素组合，B型（来自商业产品）和C型（医院生产的方便和易于管理的组合），以提供正常的饮食摄入量，同时消除任何有害的副作用。从所获得的结果来看，B型和C型患者每天服用5毫克硫胺素和3毫克硫胺素是足够和安全的水平，而a型患者每天服用55毫克硫胺素和102毫克硫胺素。
Studies were undertaken to determine rational dosages of vitamin B1 and B6 during long-term intravenous hyperalimentation, using more sensitive techniques than formerly used to evaluate B1 and B6 status. A standard vitamin combination, type A, (usually commercially available products) has been used up to now because of convenience, disregarding the effects of long-term administration. This combination lacks biotin, folic acid, and vitamin E and contains from 10 to 100 times the dietary allowances of such vitamins as B1, B2, B6, B12, and C. In response to the possibility of vitamin overdose, two new vitamin combinations, type B (from commercial products) and type C (a convenient and easily administered combination produced at the hospital) were developed in order to provide the normal dietary allowances and at the same time eliminate any harmful side-effects. From the results obtained, 5 mg/day for thiamin HCl and 3 mg/day for pyridoxine HCl in type B and type C were found to be a sufficient and safe level as opposed to 55 mg/day for thiamin HCl and 102 mg/day for pyridoxine HCl in type A.