Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.
Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.
复制标题
DOI：
10.1016/j.apsb.2016.02.001
复制
发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Nadithe V
中科院分区：
文献类型：
--
作者：
Ha D;Yang N;Nadithe V
外泌体是细胞内基于膜的小囊泡，具有不同的组成，参与多种生物和病理过程。与其他纳米颗粒药物递送系统（如脂质体和聚合物纳米颗粒）相比，外泌体作为药物递送载体的开发具有重要的优势；外泌体本质上是非免疫原性的，因为其组成与机体自身细胞相似。本文综述了外泌体的起源、结构及其生物学功能。然后，我们将重点关注外泌体作为药物递送系统在药物开发中的具体应用。概述了当使用外泌体作为药物递送载体时所面临的优势和挑战。外泌体是由各种细胞类型分泌的小泡，参与许多生物学功能。也有重要的证据表明外泌体在许多疾病中发挥着关键作用。在这里，我们讨论了它们在治疗药物输送中的潜在用途和相关性。
Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed. Exosomes are small vesicles secreted by various cell types and are involved in many biological functions. There is also significant evidence on critical role played by exosomes in many diseases. Here we discuss regarding their potential usage and relevance in therapeutic drug delivery.