Changes in regional brain volume three months after stroke
Changes in regional brain volume three months after stroke
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DOI：
10.1016/j.jns.2012.07.019
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发表时间：
2012-11-15
影响因子：
4.4
通讯作者：
Cumming, Toby
中科院分区：
文献类型：
--
作者：
Brodtmann, Amy;Pardoe, Heath;Cumming, Toby
引言：关于中风后局部脑容量的变化知之甚少。我们调查了皮质厚度的变化超过3个月的一组中风患者与controls.Material和方法：急性半球中风患者进行了研究，中风发作后3小时内，连续超过3个月。我们将急性和3个月扫描与独立采集的对照图像进行了比较。使用FreeSurfer V5.0分析高分辨率各向同性T1图像，比较区域平均皮质厚度、海马和丘脑体积。中风患者的结果分别分析同侧和对侧病灶区域，而对照组的结果在整个半球平均。两个时间点之间的百分比变化分数计算为每个参与者，配对样本t检验被用来评估显着changes.Results：12中风患者（9名男性，7左半球，平均年龄= 65.1岁）和10名对照组参与者（5名男性，平均年龄= 67.2岁）。对照组受试者的整体或区域平均皮质厚度或海马和丘脑体积估计值在2个时间点之间无显著差异。患者数据的区域变异性得到证实，特别是对侧病灶旁中央、上级额叶和岛叶区域的皮质厚度增加，这些区域已知在运动恢复的功能性MRI研究中被激活。一个显着的减少丘脑体积也被发现，最明显ipsilesionic.Conclusions：中风后的区域皮质厚度的变化是显而易见的，即使在很短的时间框架。皮质厚度的增加可能代表了代偿机制。丘脑体积的显著减少可能代表卒中后早期萎缩的证据。需要进一步的研究来证实和扩展这些初步结果。(c)2012爱思唯尔有限公司版权所有。
Introduction: Little is known about changes in regional brain volume after stroke. We investigated cortical thickness changes over 3 months in a group of stroke patients compared with controls.Material and methods: Patients with acute hemispheric stroke were studied within 3 h of stroke onset and serially over 3 months. We compared the acute and 3 month scans with independently acquired control images. High resolution isotropic T1 images were analyzed using FreeSurfer V5.0, comparing regional average cortical thickness, hippocampal and thalamic volumes. Stroke patient results were analyzed separately for ipsilesional and contralesional regions, whereas control results were averaged across hemisphere. Percentage change scores between the two time points were computed for each participant, and paired sample t-tests were used to assess significant change.Results: 12 stroke patients (9 men, 7 left-hemispheric, mean age = 65.1 years) and 10 control participants (5 men, mean age = 67.2 years) were included. There were no significant differences between the 2 time points in global or regional average cortical thickness, or hippocampal and thalamic volume estimates for control subjects. Regional variability in patient data was demonstrated, particularly cortical thickness increases in contralesional paracentral, superior frontal and insular regions, areas known to be activated in functional MRI studies of motor recovery. A significant reduction in thalamic volume was also found, most apparent ipsilesionally.Conclusions: Post-stroke changes in regional cortical thickness are demonstrable even over short time-frames. Contralesional cortical thickness increases may represent compensatory mechanisms. Significant reductions in thalamic volume may represent evidence of early post-stroke atrophy. Further studies are required to confirm and extend these preliminary results. (c) 2012 Elsevier B.V. All rights reserved.