Theta-burst stimulation over primary motor cortex degrades early motor learning
Theta-burst stimulation over primary motor cortex degrades early motor learning
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DOI：
10.1111/j.1460-9568.2010.07090.x
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发表时间：
2010-02-01
影响因子：
3.4
通讯作者：
Berardelli, Alfredo
中科院分区：
文献类型：
--
作者：
Iezzi, Ennio;Suppa, Antonio;Berardelli, Alfredo
Theta-Burst刺激(TBS)目前用于诱导初级运动皮质(M1)兴奋性的长期变化。需要更多关于M1如何参与早期运动学习的信息(与练习有关的运动表现、运动保持和运动巩固的改善)。我们调查了抑制性连续TBS(CTBS)是否是调节健康人简单手指运动的早期运动学习的一种有效的实验方法。在一项较短的任务中，11名受试者练习了160个动作，而在一项更长的任务中，10名受试者练习了600个动作。在这两个实验中，受试者在左侧M1上随机接受真实或假的CTB。分别于术前和术后7min进行运动诱发电位检测。在测试运动保持的160个动作实验中，运动训练结束30min后重复20个动作。在600个动作的实验中，在运动练习结束后15分钟和30分钟评估运动保持能力，在运动练习结束24小时后进行20个动作来测试运动巩固。测量了运动学变量--运动幅度、峰值速度和峰值加速度。在涉及160个动作的实验和涉及600个动作的实验的第一部分，CTBS显著降低了与练习有关的手指动作运动能力的提高。CTBS后，测试运动保持的20个动作的峰值速度和峰值加速度降低，而测试运动巩固的运动的峰值速度和峰值加速度保持不变。与M1相比，CTBS降低了与练习相关的运动能力和运动保持能力的改善，但不会降低自愿手指运动的运动巩固。
Theta-burst stimulation (TBS) is currently used for inducing long-lasting changes in primary motor cortex (M1) excitability. More information is needed on how M1 is involved in early motor learning (practice-related improvement in motor performance, motor retention and motor consolidation). We investigated whether inhibitory continuous TBS (cTBS) is an effective experimental approach for modulating early motor learning of a simple finger movement in healthy humans. In a short task, 11 subjects practised 160 movements, and in a longer task also testing motor consolidation ten subjects practised 600 movements. During both experiments subjects randomly received real or sham cTBS over the left M1. Motor evoked potentials were tested at baseline and 7 min after cTBS. In the 160-movement experiment to test motor retention, 20 movements were repeated 30 min after motor practice ended. In the 600-movement experiment motor retention was assessed 15 and 30 min after motor practice ended, motor consolidation was tested by performing 20 movements 24 h after motor practice ended. Kinematic variables - movement amplitude, peak velocity and peak acceleration - were measured. cTBS significantly reduced the practice-related improvement in motor performance of finger movements in the experiment involving 160 movements and in the first part of the experiment involving 600 movements. After cTBS, peak velocity and peak acceleration of the 20 movements testing motor retention decreased whereas those testing motor consolidation remained unchanged. cTBS over M1 degrades practice-related improvement in motor performance and motor retention, but not motor consolidation of a voluntary finger movement.